HISTOTRIPSY FOR THROMBOLYSIS
First Claim
1. A method for controlled mechanical fractionation of a thrombus, said method comprising:
- outputting an initiation ultrasound pulse sequence from a therapy transducer resulting in cavitation forming a targeting bubble cloud;
detecting a location of said targeting bubble cloud to define a treatment region; and
aligning said therapy transducer such that said treatment region is aligned with the thrombus.
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Accused Products
Abstract
Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”
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Citations
21 Claims
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1. A method for controlled mechanical fractionation of a thrombus, said method comprising:
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outputting an initiation ultrasound pulse sequence from a therapy transducer resulting in cavitation forming a targeting bubble cloud; detecting a location of said targeting bubble cloud to define a treatment region; and aligning said therapy transducer such that said treatment region is aligned with the thrombus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for controlled mechanical fractionation of a thrombus, said method comprising:
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outputting an initiation ultrasound pulse sequence from a therapy transducer resulting in cavitation forming a therapy bubble cloud within said treatment region; detecting formation of said therapy bubble cloud generally aligned with at least a portion of the thrombus; outputting a bubble cloud sustaining ultrasound pulse sequence; and outputting a therapy ultrasound pulse sequence which interacts with said therapy bubble cloud to produce at least partial fractionation of the thrombus. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for acoustic manipulation of at least a fragment of a thrombus, said method comprising:
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outputting an initiation ultrasound pulse sequence from a transducer resulting in cavitation forming a bubble cloud within a predetermined volume; and actuating said transducer such that the fragment of the thrombus is spatially positioned within said predetermined volume in response to said bubble cloud. - View Dependent Claims (21)
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Specification