System and Method for Distinguishing Between Hypoglycemia and Hyperglycemia Using an Implantable Medical Device
First Claim
1. A method for use with an implantable medical device for detecting one of hypoglycemia and hyperglycemia within a patient in which the device is implanted, said method comprising:
- tracking with the implantable medical device, rates of change of at least one of atrial depolarization amplitudes, ventricular depolarization amplitudes and ventricular repolarization amplitudes;
detecting with the implantable medical device, an onset of hyperglycemia upon detecting a rapid increase in at least one of the rate of change of atrial depolarization amplitudes and ventricular depolarization amplitudes; and
detecting with the implantable medical device, an onset of hypoglycemia upon detecting a rapid increase in the rate of change of ventricular repolarization amplitudes.
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Abstract
Techniques are described for detecting and distinguishing among ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one technique, these conditions are detected and distinguished based on an analysis of: the interval between the QRS complex and the peak of a T-wave (QTmax), the interval between the QRS complex and the end of a T-wave (QTend), alone or in combination with a change in ST segment elevation. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by cardiac ischemia. In another technique, hyperglycemia and hypoglycemia are predicted, detected and/or distinguished from one another based on an analysis of the amplitudes of P-waves, QRS-complexes and T-waves within the IEGM. Appropriate warning signals are delivered and therapy is automatically adjusted.
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Citations
11 Claims
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1. A method for use with an implantable medical device for detecting one of hypoglycemia and hyperglycemia within a patient in which the device is implanted, said method comprising:
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tracking with the implantable medical device, rates of change of at least one of atrial depolarization amplitudes, ventricular depolarization amplitudes and ventricular repolarization amplitudes; detecting with the implantable medical device, an onset of hyperglycemia upon detecting a rapid increase in at least one of the rate of change of atrial depolarization amplitudes and ventricular depolarization amplitudes; and detecting with the implantable medical device, an onset of hypoglycemia upon detecting a rapid increase in the rate of change of ventricular repolarization amplitudes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An implantable medical device comprising:
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a detector operative to detect at least one of atrial depolarization amplitudes, ventricular depolarization amplitudes and ventricular repolarization amplitudes; and a processor operative to; track rates of change of at least one of atrial depolarization amplitudes, ventricular depolarization amplitudes and ventricular repolarization amplitudes; detect an onset of hyperglycemia upon detecting a rapid increase in at least one of the rate of change of atrial depolarization amplitudes and ventricular depolarization amplitudes; and detect an onset of hypoglycemia upon detecting a rapid increase in the rate of change of ventricular repolarization amplitudes.
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11. An implantable medical device comprising:
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a detector operative to detect at least one of atrial depolarization amplitudes, ventricular depolarization amplitudes and ventricular repolarization amplitudes; and a processor operative to; track amplitude-based parameters within electrical cardiac signals over time corresponding to amplitudes of atrial depolarizations, ventricular depolarizations and ventricular repolarizations; detect hyperglycemia upon detection of an increase in atrial depolarization amplitudes, an increase in ventricular depolarization amplitudes and a lack of significant change in ventricular repolarization amplitudes; and detect hypoglycemia upon detection of a lack of significant change in atrial depolarization amplitudes, an increase in ventricular depolarization amplitudes and an increase in ventricular repolarization amplitudes.
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Specification