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Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof

  • US 20090181032A1
  • Filed: 02/20/2009
  • Published: 07/16/2009
  • Est. Priority Date: 03/05/2003
  • Status: Active Grant
First Claim
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1. A substantially purified hyaluronidase polypeptide, comprising at least one sugar moiety that is covalently attached to an asparagine residue of the hyaluronidase polypeptide, wherein:

  • the substantially purified hyaluronidase polypeptide is soluble;

    the soluble hyaluronidase polypeptide is a neutral active glycoprotein; and

    the substantially purified hyaluronidase comprises a sequence of amino acids included in SEQ ID NO;

    1 or a sequence that has at least about 91% amino acid sequence identity with a sequence of amino acids included in SEQ ID NO;

    1.

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