THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEREOF AND USE THEREOF
First Claim
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1. A poly(organophosphazene)-bioactive molecule conjugate in which a biodegradable and thermosensitive poly(organophosphazene) with a functional group represented by the following Chemical Formula 1 and a bioactive molecule represented by the following substituent R10 are combined:
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Abstract
The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.
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22 Claims
- 1. A poly(organophosphazene)-bioactive molecule conjugate in which a biodegradable and thermosensitive poly(organophosphazene) with a functional group represented by the following Chemical Formula 1 and a bioactive molecule represented by the following substituent R10 are combined:
- 6. A poly(organophosphazene) hydrogel containing poly(organophosphazene)-bioactive molecule conjugate of the following Chemical Formula 1 showing sol-gel phase transition with change of temperature:
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