Molecular Cage for Sustained Release Control of Pharmaceutical and Cosmetic Agents
First Claim
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1. A method of making a molecular caging complex as a sustained release formulation, comprising:
- providing caging molecules and second molecules to be caged by the caging molecules, where caging molecules are provided in excess of the second molecules;
mixing the caging molecules and the second molecules;
opening the caging molecules to allow the second molecules to be associated with the caging molecules;
closing the caging molecules such that one or more second molecules are confined within one caging molecule to make a molecular caging complex,wherein opening and closing the caging molecules are controlled by changing thermodynamic parameters including temperature and/or pressure, evaporating a solvent of the caging molecule, inducing a phase transition, or taking a solution with the caging molecules into a supercritical state, andwherein the caging molecules are polymers, biomolecules, polysaccharides, or organic or inorganic molecules in which each forms a cage structure that confines one or more of the second molecules.
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Abstract
A method of making and using molecular cages is provided to control the release of molecules entrapped or caged within a caging molecule. The caging molecule may be a polymer, cellulose, or an organic and inorganic molecule that exhibits structural swelling, phase transitions, or structural rearrangement by changing thermodynamic parameters such as temperature and/or pressure. The caging molecule may also be accompanied by a co-caging molecule, which is also confined within the caging molecule, to further control the release of the caged molecules.
28 Citations
21 Claims
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1. A method of making a molecular caging complex as a sustained release formulation, comprising:
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providing caging molecules and second molecules to be caged by the caging molecules, where caging molecules are provided in excess of the second molecules; mixing the caging molecules and the second molecules; opening the caging molecules to allow the second molecules to be associated with the caging molecules; closing the caging molecules such that one or more second molecules are confined within one caging molecule to make a molecular caging complex, wherein opening and closing the caging molecules are controlled by changing thermodynamic parameters including temperature and/or pressure, evaporating a solvent of the caging molecule, inducing a phase transition, or taking a solution with the caging molecules into a supercritical state, and wherein the caging molecules are polymers, biomolecules, polysaccharides, or organic or inorganic molecules in which each forms a cage structure that confines one or more of the second molecules. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A composition comprising:
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one or more second molecules; a caging molecule for confining one or more second molecules within the caging molecule; and a co-caging molecule to fill the caging molecule to further confine the second molecules; and
the co-caging molecule also being confined within the caging molecule,wherein the caging molecule is a polymer, biomolecule, polysaccharide, or organic or inorganic molecule in which each forms a cage structure that confines one or more of the second molecules. - View Dependent Claims (9, 10, 11)
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12. A method of treatment, comprising:
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administering to a subject a formulation containing a caging complex, wherein the caging complex comprises; one or more second molecules; a caging molecule for confining one or more second molecules within the caging molecule; a co-caging molecule to fill the caging molecule to further confine the second molecules; and
the co-caging molecule also being confined within the caging molecule,wherein the caging molecule is a polymer, biomolecule, polysaccharide, or organic or inorganic molecule in which each forms a cage structure that confines one or more of the second molecules. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method of deterring drug abuse, comprising:
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providing a formulation containing a caging complex, wherein the caging complex comprises; one or more second molecules; a caging molecule for confining one or more second molecules within the caging molecule; a co-caging molecule to fill the caging molecule to further confine the second molecules; and
the co-caging molecule also being confined within the caging molecule,wherein the second molecules are prevented from being abused by having the caging molecule acting as a barrier against rapid release to the environment external to the caging complex, and wherein the caging molecule is a polymer, biomolecule, polysaccharide, or organic or inorganic molecule in which each forms a cage structure that confines one or more of the second molecules. - View Dependent Claims (19, 20, 21)
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Specification