Cancer Risk Biomarker

• US 20090181383A1
• Filed: 09/17/2008
• Published: 07/16/2009
• Est. Priority Date: 09/17/2007
• Status: Active Grant

• Current Assignee: University of Toledo
• Original Assignee: University of Toledo
• Inventors: WILLEY, JAMES C., MULLINS, D'ANNA N., BLOMQUIST, THOMAS M., CRAWFORD, ERIN L.
• Granted Patent: US 8,765,368 B2
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: C12Q 1/6886 for cancer immunoassay for cancer G01N33/574
• CPC Class Codes: C12Q 2545/114 involving a quantitation step
• CPC Class Codes: C12Q 2600/158 Expression markers
• CPC Class Codes: C12Q 2600/16 Primer sets for multiplex assays
• CPC Class Codes: G01N 2800/50 Determining the risk of developing a disease
• CPC Class Codes: G01N 33/574 for cancer

Abstract

The present disclosure relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer. Also provided are methods and compositions for identifying a greater risk for a cancer-related condition in an subject.

Claims

1. A method of identifying a greater risk for a cancer-related condition in an subject comprising obtaining a cancer risk index comprising:

(a) determining transcript abundance (TA) for one or more genes, wherein at least one gene is an antioxidant gene, a DNA repair (DNAR) gene, or a transcription factor gene that is significantly associated with diagnosis of cancer;

(b) determining a threshold level for each of said TA(s); and

,

(c) determining if said TA(s) is above or below said threshold level wherein said threshold level indicates whether said subject is at greater risk for a cancer-related condition.

2. The method as recited in claim 1, wherein said cancer-related condition is bronchogenic carcinoma, a lung-cancer, or a risk thereof.

3. The method of claim 1, wherein said threshold levels are determined for at least three genes selected from a group of genes consisting of:

CEBPG, E2F1, E2F6, XRCC1, ERCC4, ERCC5, GPX1, GPX3, GSTM3, GSTP1, GSTT1, GSTZ1, MGST1, SOD1 and CAT.

4. The method of claim 1, wherein said threshold levels are determined for CEBPG, E2F1, E2F6, XRCC1, ERCC4, ERCC5, GPX1, GPX3, GSTM3, GSTP1, GSTT1, GSTZ1, MGST1, SOD1 and CAT.

5. The method of claim 1, wherein said transcription factor is CEBPG.