Mesoderm And Definitive Endoderm Cell Populations
First Claim
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1. A developmentally normal embryonic stem cell in which a nucleic acid encoding a first selectable marker is operably linked to brachyury regulatory elements and wherein one brachyury allele is inactivated by said nucleic acid and said first selectable marker is expressed.
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Abstract
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
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5 Claims
- 1. A developmentally normal embryonic stem cell in which a nucleic acid encoding a first selectable marker is operably linked to brachyury regulatory elements and wherein one brachyury allele is inactivated by said nucleic acid and said first selectable marker is expressed.
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5. A developmentally normal embryonic stem cell in which a nucleic acid encoding green fluorescent protein is operably linked to brachyury regulatory elements, and wherein one brachyury allele is inactivated by said nucleic acid encoding green fluorescent protein.
Specification