THERAPEUTIC CANCER TREATMENTS
First Claim
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1. A method of extending relapse free survival in a cancer patient who is undergoing treatment with a chemotherapeutic, the method comprising administering a therapeutically effective amount of a hedgehog inhibitor to the patient.
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Abstract
The invention is directed to use of hedgehog inhibitors in conjunction with chemotherapy in treating cancers, and preventing relapses thereby.
111 Citations
37 Claims
- 1. A method of extending relapse free survival in a cancer patient who is undergoing treatment with a chemotherapeutic, the method comprising administering a therapeutically effective amount of a hedgehog inhibitor to the patient.
- 15. A method of extending relapse free survival in a cancer patient who had previously been treated with a chemotherapeutic, the method comprising administering a therapeutically effective amount of a hedgehog inhibitor to the patient after treatment with the chemotherapeutic has ceased.
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17. The method of claim 17, wherein the lung cancer is selected from small cell lung cancer and non-small cell lung cancer.
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26. A method of treating pancreatic cancer, the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula I:
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or a pharmaceutically acceptable salt thereof. - View Dependent Claims (27, 28, 29, 30, 31)
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- 32. A method of treating cancer in a patient wherein the patient is undergoing other cancer therapy, the method comprising detecting elevated hedgehog ligand in the patient and administering a pharmaceutically effective amount of a hedgehog antagonist to the patient.
- 36. A method of treating cancer in a patient, the method comprising identifying one or more chemotherapeutics that elevate hedgehog ligand expression in a tumor, and administering a therapeutically effective amount of the one or more chemotherapeutics that elevate hedgehog ligand expression in the tumor and a therapeutically effective amount of a hedgehog inhibitor.
Specification