Alicyclic Heterocyclic Compound

• US 20090182140A1
• Filed: 11/30/2006
• Published: 07/16/2009
• Est. Priority Date: 12/02/2005
• Status: Abandoned Application

• Current Assignee: Mitsubishi Tanabe Pharma Corporation (Mitsubishi Chemical Group Corp.)
• Original Assignee: Mitsubishi Tanabe Pharma Corporation (Mitsubishi Chemical Group Corp.)
• Inventors: Miyazaki, Hiroshi, Furukubo, Shigeru
• Application Number:
  US12/085,921
• Publication Number:
  US 20090182140A1
• Time in Patent Office: Days
• US Class Current: 540/552
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 237/24 Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 239/95 with hetero atoms directly attached in positions 2 and 4
• CPC Class Codes: C07D 241/28 in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
• CPC Class Codes: C07D 253/075 Two hetero atoms, in positions 3 and 5
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 487/04 Ortho-condensed systems
• CPC Class Codes: C07D 495/04 Ortho-condensed systems
• CPC Class Codes: C07D 498/04 Ortho-condensed systems

Abstract

An alicyclic heterocyclic compound represented by the following formula or a pharmaceutically acceptable salt thereof:

wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., P¹ and P² are CH or N, q and r are 0 to 2, X is —NH—, —O—, —CH₂—, etc., Y is —CH₂—, —CO—, —SO₂—, etc., Z is —CO—, —SO₂—, etc., and R³ is carbocyclic group, heterocyclic group, hydroxyl, alkoxy or amino,
is useful as a controlling agent of the function of CCR⁴ useful for the prevention or treatment for bronchial asthma, atopic dermatitis, etc.

Claims

1. An aromatic compound represented by the following formula (I):

wherein ring A is a group selected from the group consisting of the following formulas;

, ring B is an optionally substituted aromatic carbocyclic ring or an optionally substituted heterocyclic ring,

G¹, G², G³, G⁴ and G⁵ are each the same or different, and CH or N, provided that two or more among G¹, G², G³, G⁴ and G⁵ are CH,

Q is oxygen atom, sulfur atom or —

N(R⁶),

m is an integer of 1 or 2, n is an integer of 1 to 3,

w is an integer of 0, 1 or 2,

X is —

N(R⁷)—

, —

O—

or —

C(R⁸)(R⁹)—

,

Y is —

C(R¹⁰)(R¹¹)—

, —

CO—

or —

SO₂—

,

Z is a single bond, —

CO—

, —

SO₂—

, —

N(R¹²)—

, —

CON(R¹³)—

, —

SO₂N(R¹³)—

, —

N(R¹³)CO—

, —

N(R¹³)SO₂—

, —

N(R¹⁴)CON(R¹⁵)—

or —

N(R¹⁴)SO₂N(R¹⁵)—

,

R¹ is hydrogen atom, alkyl group, alkoxy group, halogen atom, carboxy group, alkoxycarbonyl group, optionally substituted carbamoyl group, optionally substituted amino group, nitro group or optionally substituted ureido group,

R² is hydrogen atom, alkyl group, alkoxy group, halogen atom, haloalkyl group, carboxy group, alkoxycarbonyl group, optionally substituted carbamoyl group or optionally substituted amino group,

R³ is optionally substituted carbocyclic group, optionally substituted heterocyclic group or optionally substituted alkyl group,

R⁴ is hydrogen atom or alkyl group,

R⁵ is hydrogen atom, alkyl group or optionally substituted alkanoyl group,

R⁶ is hydrogen atom, alkyl group or optionally substituted alkanoyl group,

R⁷ is hydrogen atom or alkyl group,

R⁸ and R⁹, or R¹⁰ and R¹¹ are each the same or different, and hydrogen atom or alkyl group,

R¹² is hydrogen atom, alkyl group, alkanoyl group or carboxyalkyl group,

R¹³ is hydrogen atom or alkyl group, and

R¹⁴ and R¹⁵ are each the same or different, and hydrogen atom or alkyl group,

or a pharmaceutically acceptable salt thereof.

2. The aromatic compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein ring A is a group selected from the groups consisting of the following formulas:

, wherein each signal is the same as defined above.

3. The aromatic compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein ring A is a group selected from the group consisting of the following formulas:

, wherein each signal is the same as defined above.

4. The aromatic compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein Z is a single bond, —

CONH—

, —

NHCO—

or —

CO—

.

5. The aromatic compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein R³ is

(1) pyrrolidinyl group which is optionally substituted by (a) oxo group, (b) hydroxymethyl group, (c) alkyl group, (d) amino group which is optionally substituted by one or two alkyl group(s), or (e) carbamoyl group which is optionally substituted by one or two alkyl group(s),

(2) piperidinyl group which is optionally substituted by alkyl group, alkanoyl group, cyano group, amino group which is optionally substituted by one or two alkyl group(s) or oxo group,

(3) piperadinyl group which is optionally substituted by alkyl group,

(4) morpholinyl group which is optionally substituted by alkyl group, or

(5) tetrahydropyridyl group which is optionally substituted by alkyl group.

6. The aromatic compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein X is —

NH—

, Y is —

CH₂—

, —

CH(CH₃)—

or —

C(CH₃)₂—

, and ring B is benzene which is substituted by one or two substituents selected from the group consisting of halogen atom, alkyl group and haloalkyl group.