Method for making amphiphilic dendrimers

• US 20090182151A1
• Filed: 07/18/2006
• Published: 07/16/2009
• Est. Priority Date: 07/18/2005
• Status: Abandoned Application

• Current Assignee: The Scripps Research Institute
• Original Assignee: The Scripps Research Institute
• Inventors: Fokin, Valery V., Wu, Peng, Sharpless, K. Barry
• Application Number:
  US11/989,072
• Publication Number:
  US 20090182151A1
• Time in Patent Office: Days
• US Class Current: 548/255
• CPC Class Codes: C08G 63/06 derived from hydroxycarboxylic acids
• CPC Class Codes: C08G 83/003 Dendrimers

Abstract

A series of AB-type amphiphilic dendritic polyesters have been prepared divergently, in which two hybrids were coupled via the copper(1)-catalyzed triazole formation.

Claims

1. A process for making a di-block dendrimer having a first dendritic block and a second dendritic block, said first dendritic block having a first block core, said second dendritic block having a second block core, said process comprising the step of coupling the first block core to the second block core by means of a click chemistry reaction to form the di-block dendrimer having a di-block core.

2. A process according to claim 1 wherein the click chemistry reaction is a copper(I)-catalyzed 1,3-dipolar cycloaddition of a terminal acetylene with an azide to form a [1,2,3]-triazole.

3. A process according to claim 1 wherein the first block core includes a terminal acetylene and the second core block includes an azide.

4. A process according to claim 1 wherein the first dendritic block includes a first periphery, the second dendritic block includes a second periphery, and the first periphery differs from the second periphery.

5. An improved dendritic block having a block core characterized by having a terminal acetylene.

6. An improved dendritic block having a block core characterized by having an azide.

7. An improved di-block dendrimer having a first dendritic block, a second dendritic block, and a di-block core that couples the first dendritic block to the second dendritic block, the di-block core being characterized by a [1,2,3]-triazole ring that couples the first dendritic block to the second dendritic block.