Oral Care Composition to Reduce or Eliminate Dental Sensitivity

• US 20090186090A1
• Filed: 01/21/2009
• Published: 07/23/2009
• Est. Priority Date: 04/30/2007
• Status: Abandoned Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Prencipe, Michael, Wang, Qin, Christopoulou, Constantina, Chopra, Suman K., Zaidel, Lynette
• Application Number:
  US12/356,837
• Publication Number:
  US 20090186090A1
• Time in Patent Office: Days
• US Class Current: 424/489
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/8164 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and includes, in part, particles having a particle size of 2-5 microns. Also included within the scope of the invention are methods comprising the use of such compositions, such as methods of reducing dental sensitivity.

Claims

1. An oral care composition comprising:

a. an adherent material; and

b. silica particles,

wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

11. The composition of claim 1, wherein the silica particles have a porosity of less than 0.45 cc/g in pores of 600 Angstroms or smaller.

12. The composition of claim 1, wherein adherent material is a polymer having a number average molecular weight between 100,000 and 2,500,000, inclusive.

13. The composition of claim 1, wherein the adherent material is selected from polymers of polyvinyl phosphonic acid, poly(l-phosphonopropene) sulfonic acid, poly(beta styrene phosphonic acid), alpha styrene phosphonic acid, synthetic anionic polymeric polycarboxylate, maleic anhydride, maleic acid, and methyl vinyl ether.

14. The composition of claim 1, wherein the adherent molecule is a polymer of methyl vinyl ether and maleic anhydride.

15. The composition of claim 1, wherein the composition is formulated into a form selected from a rinse, a paste, a gel, a gum, a dissolvable lozenge, and a film.

16. The composition of claim 1, wherein the composition is formulated into a form selected from a dissolvable film.

17. The composition of claim 1, further comprising a non-silica desensitizing agent.

18. The composition of claim 17, wherein the desensitizing agent is selected from the group consisting of a nitrate salt, an arginine ester, a bicarbonate salt, potassium nitrate, potassium chloride, an arginine-bicarbonate-phytate complex, potassium citrate, and arginine.

19. The composition of claim 1, further comprising an antibacterial agent.

20. The composition of claim 1, further comprising an agent selected from a chemical whitening agent, an opaque whitening agent and an anticalculus agent.

21. The composition of claim 1, further comprising 2,4,4′

-trichloro-2′

-hydroxydiphenyl ether.

22. The composition of claim 1, further comprising a surfactant system that comprises sodium lauryl sulfate and tauranol.

23. The composition of claim 1, further comprising a surfactant system that consists essentially of sodium lauryl sulfate and tauranol in a ratio of 1:

5 to 1;

3.

24. The composition of claim 1, further comprising an agent selected from a stannous ion agent;

a fluoride compound;

sodium fluoride;

chlorhexidine;

alexidine;

hexetidine;

sanguinarine;

benzalkonium chloride;

salicylanilide;

domiphen bromide;

cetylpyridinium chloride (CPC);

tetradecylpyridinium chloride (TPC);

N-tetradecyl-4-ethylpyridinium chloride (TDEPC);

octenidine;

delmopinol;

octapinol;

nisin;

zinc ion agent;

copper ion agent;

essential oils;

furanones;

bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creatine, and propolis.

25. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth an oral care composition of claim 1.

26. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth an oral care composition of claim 1, wherein the adherent material is selected from polymers of polyvinyl phosphonic acid, poly(l-phosphonopropene)sulfonic acid, poly(beta styrene phosphonic acid), alpha styrene phosphonic acid, synthetic anionic polymeric polycarboxylate, maleic anhydride, maleic acid, and methyl vinyl ether.

27. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth an oral care composition of claim 1, wherein the particles have a porosity of less than 0.45 cc/g in pores of 600 Angstroms or smaller.

28. A method of protecting dental from acid-mediated degradation, comprising applying to the surface of a mammalian tooth an oral care composition of claim 1.

29. A method of maintaining or increasing the systemic health of a mammal comprising applying a composition to an oral surface of a man mal at least once a day for a duration of time, wherein the composition comprises:

a. an oral care composition of claim 1, wherein the silica particles are present in the composition in an amount of 5% by weight or greater, and

b. an agent selected from triclosan;

triclosan monophosphate;

chlorhexidine;

alexidine;

hexetidine;

sanguinarine;

benzalkonium chloride;

salicylanilide;

domiphen bromide;

cetylpyridinium chloride (CPC);

tetradecylpyridinium chloride (TPC);

N-tetradecyl-4ethylpyridinium chloride (TDEPC);

octenidine;

delmopinol;

octapinol;

nisin;

zinc ion agent;

copper ion agent;

essential oils;

furanones;

bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, fluoride, stannous ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creative, and propolis.

31. A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the tooth surface the composition of claim 1.

32. The method of claim 31, wherein the method of application is a method other than brushing the tooth surface.

33. A method of desensitizing a tooth in less than one day, the method comprising applying to the tooth surface the composition of claim 1.

34. A method of increasing the potassium flux through one or more dentin tubules, the method comprising applying to a tooth surface the composition of claim 1.

35. A method of increasing the potassium flux of a conventional potassium-containing desensitizing dentifrice, the method comprising applying to the tooth surface the composition of claim 1, wherein the composition is applied:

(a) prior to application of the conventional dentifrice to the tooth,

(b) concomitant with application of the conventional dentifrice to the tooth, or

(c) concomitant with application of the conventional dentifrice to the tooth in a mixture with the conventional dentifrice,

or by way of any combination of (a)-(c).

2. A oral care composition comprising:

a. an adherent material; and

b. silica particles having a particle size distribution (PSD) of 2 μ

m to 5 μ

m,

wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

3. An oral care composition comprising:

a. an adherent material; and

b. silica particles having a median particle size of 2 μ

m to 5 μ

m,

wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

4. An oral care composition comprising:

a. an adherent material; and

b. silica particles having an average particle size of 2 μ

m to 5 μ

m,

wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

5. An oral care composition comprising:

a. an adherent material; and

b. silica particles having an average particle size of 2.7 μ

m to 4.0 μ

m,

wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

6. An oral care composition comprising:

a. an adherent material; and

b. a population of silica particles having a particle size selected from the group consisting of 2 μ

m, 2.5 μ

m, 3 μ

m, 3.5 μ

m, 4 μ

m, 4.5 μ

m, and 5 μ

m, wherein said population of silica particles comprise at least 20% of the total silica particles in said oral care composition,

wherein the oral care composition provides a fluid flour rate of no greater than about 45% of the fluid flow rate of etched dentin.

7. An oral care composition comprising:

a. an adherent material; and

b. silica particles having a median particle size of 3 μ

m to 5 μ

m, a d₁₀ of 1.5 μ

m to 3 μ

m, and a d₉₀ of 6 μ

m to 11 μ

m,

wherein the oral care composition provides a fluid flown, rate of no greater than about 45% of the fluid flow %, rate of etched dentin.

8. An oral care composition comprising:

a. an adherent material; and

b. silica particles having a median particle size of 2 μ

m to 4 μ

m, a d₁₀ of 0.5 μ

m to 2 μ

mil, and a d₉(o of 5 μ

m to 10 μ

m,

wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

9. An oral care composition comprising:

a. an adherent material; and

b. silica particles,

wherein the composition has a cumulative particle size volume (AUC 3.95) of at least 20%, and wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

10. An oral care composition comprising:

a. an adherent material; and

b. silica particles,

wherein the silica particles comprise a population of starting material silica particles having a cumulative particle size volume (AUC 3.95) of at least 40%, wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

30. A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the tooth surface a composition comprising an adherent material and a silica particle having a median particle size of no greater than a dentin tubule.