DEVICE AND SUBSTANCE FOR THE IMMOBILIZATION OF MESENCHYMAL STEM CELLS (MSCs)
First Claim
1. A device comprising at least one surface which comes into contact with biological tissue and/or liquid, which is at least partially coated with a substance which mediates the binding of mesenchymal stem cells (MSCs), wherein the substance is an aptamer.
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Accused Products
Abstract
The invention relates to a device comprising at least one surface which comes into contact with biological tissue and/or liquid, which is at least partially coated with a substance which mediates the binding of mesenchymal stem cells (MSCs), a method for the binding and/or isolation of MSCs from biological tissue and/or liquid, a nucleic acid molecule which selectively and highly specifically binds to MSCs, the use of the nucleic acid molecule for the binding and/or isolation of MSCs from biological tissue and/or liquid, as well as a method for the production of a device mentioned at the outset.
12 Citations
16 Claims
- 1. A device comprising at least one surface which comes into contact with biological tissue and/or liquid, which is at least partially coated with a substance which mediates the binding of mesenchymal stem cells (MSCs), wherein the substance is an aptamer.
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9. A method for the isolation of mesenchymal stem cells (MSCs) from biological tissue and/or liquid, comprising the following steps:
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(1) providing biological tissue containing MSCs and/or biological liquid containing MSCs, (2) contacting said tissue and/or said liquid with a substance which binds to MSCs, (3) incubating for a period of time which is sufficient for the binding of the MSCs to the substance, and (4) isolating the MSCs which are bound to the substance, wherein the substance is an aptamer. - View Dependent Claims (10, 11, 12)
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- 13. A nucleic acid molecule, which is designed in such a manner that it selectively and highly specifically binds to mesenchymal stem cells (MSCs).
Specification