Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell
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Abstract
The invention provides cell penetrating peptide-nucleic acid conjugates having the formula P-L-N, wherein P is a cell penetrating peptide, N is a nucleic acid, preferably an oligonucleotide and more preferably a siRNA, and L is a hydrophilic polymer, preferably a polyethylene glycol (PEG)-based linker linking P and N together. Compositions, methods of use and methods for producing such conjugates are also disclosed.
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28 Claims
- 1. A compound having the formula I:
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23. (canceled)
Specification