COMPOSITIONS COMPRISING N-PROPANOYL DERIVATIVES OF AMINO ACIDS, AMINOCARBOHYDRATES AND DERIVATIVES THEREOF

• US 20090186853A1
• Filed: 04/03/2009
• Published: 07/23/2009
• Est. Priority Date: 03/16/2005
• Status: Abandoned Application

• Current Assignee: Eugene J Van Scott, Ruey J. Yu
• Original Assignee: Eugene J Van Scott, Ruey J. Yu
• Inventors: Van Scott, Eugene J., YU, Ruey J.
• Application Number:
  US12/418,144
• Publication Number:
  US 20090186853A1
• Time in Patent Office: Days
• US Class Current: 514/62
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/7008 Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

The embodiments relate to compositions comprising therapeutically effective amounts of at least one N-propanoyl derivative of amino acids, aminocarbohydrates, and derivatives thereof. The compositions are useful the prevention and treatment of symptoms or syndromes associated with nervous, vascular, musculoskeletal, or cutaneous systems. The compositions may be topically or systemically administered to a subject in need thereof.

Claims

1. (canceled)

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22. (canceled)

23. A method of alleviating or improving a cosmetic or dermatological condition comprising topical administration of a composition comprising an N-propanoyl derivative of aminomonosaccharide, as stereoisomeric or non-stereoisomeric form, wherein the cosmetic or dermatological condition is selected from the group consisting of acne;

blemished skin;

blotches;

dandruff;

dry skin;

xerosis;

uneven and rough surface of skin, nail and hair;

itch;

pruritus;

eczema;

ichthyosis;

keratoses;

hyperkeratoses;

age spots;

lentigines;

melasmas;

mottled skin;

pseudofolliculitis barbae;

photoaging, photodamage;

dermatoses;

psoriasis;

thinning of skin, nail plate and hair;

cellulite;

stretch marks;

skin lines;

wrinkles;

defective synthesis or repair of dermal components;

abnormal or diminished synthesis of collagen, glycosaminoglycans, proteoglycans and elastin as well as diminished levels of such components in the dermis;

loss or reduction of skin, nail and hair resiliency, elasticity and recoilability;

lack of skin, nail and hair lubricants and luster;

fragility and splitting of nail and hair;

yellowing skin;

reactive, irritating or telangiectatic skin;

dull and older-looking skin, nail and hair;

for skin bleach and lightening; and

wound healing.

24. The method of claim 23, wherein the N-propanoyl derivative of aminomonosaccharide is selected from the group consisting of N-propanoyl-glycerosamine, N-propanoyl-erythrosamine, N-propanoyl-threosamine, N-propanoyl-ribosamine, N-propanoyl-arabinosamine, N-propanoyl-xylosamine, N-propanoyl-lyxosamine, N-propanoyl-allosamine, N-propanoyl-altrosamine, N-propanoyl-glucosamine, N-propanoyl-mannosamine, N-propanoyl-gulosamine, N-propanoyl-idosamine, N-propanoyl-galactosamine, N-propanoyl-mannosamine, N-propanoyl-talosamine, N-propanoyl-alloheptosamine, N-propanoyl-altroheptosamine, N-propanoyl-glucoheptosamine, N-propanoyl-mannoheptosamine, N-propanoyl-guloheptosamine, N-propanoyl-idoheptosamine, N-propanoyl-galactoheptosamine and N-propanoyl-taloheptosamine, as stereoisomeric or non-stereoisomeric form,

25. The method of claim 24, wherein the cosmetic or dermatological condition is selected from the group consisting of acne;

dry skin;

itch;

eczema;

ichthyosis;

age spots;

lentigines;

melasmas;

psoriasis;

photoaging;

photodamage;

skin lines;

wrinkles; and

for skin bleach and lightening.

26. The method of claim 25, wherein the N-propanoyl derivative of aminomonosaccharide is selected from the group consisting of N-propanoyl-glucosamine, N-propanoyl-mannosamine and N-propanoyl-galactosamine.

27. The method of claim 23, wherein the N-propanoyl derivative of aminomonosaccharide is selected from the group consisting of N-propanoyl-glyceraminic acid, N-propanoyl-erythrosaminic acid, N-propanoyl-threosaminic acid, N-propanoyl-ribosaminic acid, N-propanoyl-arabinosaminic acid, N-propanoyl-xylosaminic acid and N-propanoyl-lyxosaminic acid, N-propanoyl-allosaminic acid, N-propanoyl-altrosaminic acid, N-propanoyl-glucosaminic acid, N-propanoyl-mannosaminic acid, N-propanoyl-gulosaminic acid, N-propanoyl-idosaminic acid, N-propanoyl-galactosaminic acid, N-propanoyl-talosaminic acid, N-propanoyl-alloheptosaminic acid, N-propanoyl-altroheptosaminic acid, N-propanoyl-glucoheptosaminic acid, N-propanoyl-mannoheptosaminic acid, N-propanoyl-guloheptosaminic acid, N-propanoyl-idoheptosaminic acid, N-propanoyl-galactoheptosaminic acid, N-propanoyl-taloheptosaminic acid, N-propanoylmuramic acid, N-propanoylneuramine, N-propanoyl-neuraminic acid. N-propanoyl-glycerosylamine, N-propanoyl-erythrosylamine, N-propanoyl-threosylamine, N-propanoyl-ribosylamine, N-propanoyl-arabinosylamine, N-propanoyl-xylosylamine, N-propanoyl-lyxosylamine, N-propanoyl-allosylamine, N-propanoyl-altrosylamine, N-propanoyl-glucosylamine, N-propanoyl-mannosylamine, N-propanoyl-gulosylamine, N-propanoyl-idosylamine, N-propanoyl-galactosylamine, N-propanoyl-talosylamine, N-propanoyl-alloheptosylamine, N-propanoyl-altroheptosylamine, N-propanoyl-glucoheptosylamine, N-propanoyl-mannoheptosylamine, N-propanoyl-guloheptosylamine, N-propanoyl-idoheptosylamine, N-propanoyl-galactoheptosylamine, N-propanoyl-taloheptosylamine, and N-propanoyl-aminocyclitols, as free acid, salt, partial salt, amide, ester or lactone form.

28. The method of claim 23, wherein the composition further comprises an additional cosmetic, pharmaceutical, or other agent to achieve synergetic or synergistic effects.

29. A method of alleviating or improving a cosmetic or dermatological condition comprising topical administration of a composition comprising an N-propanoyl derivative of amino acid, as stereoisomeric, non-stereoisomeric, free acid, salt, partial salt, amide, ester or lactone form;

wherein the N-propanoyl derivative of amino acid is selected from the group consisting of N-propanoyl-alanine, N-propanoyl-arginine, N,N-dipropanoyl-arginine, N-propanoyl-asparagine, N-propanoyl-aspartic acid, N-propanoyl-cysteine, N-propanoyl-glycine, N-propanoyl-glutamic acid, N-propanoyl-glutamine, N-propanoyl-histidine;

N,N-dipropanoyl-histidine, N-propanoyl-isoleucine, N-propanoyl-leucine, N-propanoyl-lysine;

N,N-dipropanoyl-lysine, N-propanoyl-methionine, N-propanoyl-phenylalanine, N-propanoyl-serine, N-propanoyl-threonine, N-propanoyl-tryptophan, N,N-dipropanoyl-tryptophan, N-propanoyl-tyrosine, and N-propanoyl-valine, N-propanoyl-β

-alanine, N-propanoyl-γ

-aminobutanoic acid, N-propanoyl-β

-aminoisobutanoic acid, N-propanoyl-citrulline, N-propanoyl-dopa (N-propanoyl-3,4-dihydroxyphenylalanine), N-propanoyl-homocysteine, N-propanoyl-homoserine, N-propanoyl-ornithine, and N,N-dipropanoyl-ornithine.

30. The method of claim 30, wherein the cosmetic or dermatological condition is selected from the group consisting of acne;

blemished skin;

blotches;

dandruff;

dry skin;

xerosis;

uneven and rough surface of skin, nail and hair;

itch;

pruritus;

eczema;

ichthyosis;

keratoses;

hyperkeratoses;

age spots;

lentigines;

melasmas;

mottled skin;

pseudofolliculitis barbae;

photoaging;

photodamage;

dermatoses;

psoriasis;

thinning of skin, nail plate and hair;

cellulite;

stretch marks;

skin lines;

wrinkles;

defective synthesis or repair of dermal components;

abnormal or diminished synthesis of collagen, glycosaminoglycans, proteoglycans and elastin as well as diminished levels of such components in the dermis;

loss or reduction of skin, nail and hair resiliency, elasticity and recoilability;

lack of skin, nail and hair lubricants and luster;

fragility and splitting of nail and hair;

yellowing skin;

reactive, irritating or telangiectatic skin;

dull and older-looking skin, nail and hair;

for skin bleach and lightening; and

wound healing.

31. The method of claim 30, wherein the N-propanoyl derivative of amino acid is selected from the group consisting of N-propanoyl-arginine, N-propanoyl-asparagine, N-propanoyl-aspartic acid, N-propanoyl-cysteine, N-propanoyl-glycine, N-propanoyl-glutamine, N-propanoyl-glutamic acid, N-propanoyl-lysine, N-propanoyl-serine, N-propanoyl-threonine, N-propanoyl-tryptophan, N-propanoyl-tyrosine, N-propanoyl-P-alanine, N-propanoyl-γ

-aminobutanoic acid and N-propanoyl-ornithine.

32. The method of claim 30, wherein the composition further comprises an additional cosmetic, pharmaceutical, or other agent to achieve synergetic or synergistic effects.

33. A method of alleviating or improving a cosmetic or dermatological condition comprising topical administration of a composition comprising N-propanoyl-proline as stereoisomeric, non-stereoisomeric, free acid, salt, partial salt, amide, ester form wherein the cosmetic or dermatological condition is selected from the group consisting of acne;

uneven and rough surface of skin;

itch;

pruritus;

eczema;

ichthyosis;

keratoses;

hyperkeratoses;

age spots;

lentigines;

melasmas;

pseudofolliculitis barbae;

psoriasis;

thinning of skin;

for skin bleach and lightening; and

wound healing.

34. The method of claim 33, wherein the composition further comprises an additional cosmetic, pharmaceutical, or other agent to achieve synergetic or synergistic effects.