Novobiocin Analogues
First Claim
Patent Images
1. Compounds according to the formula:
- wherein R1 is an amido which is NR′
COR″
, and R′
is hydrogen and R″
is aryl or heterocycle;
wherein R2 is hydrogen, hydroxy, or —
R8—
OR9, wherein R8 is a covalent bond or alkyl, and R9 is C-amido or acyl;
or R2 together with R3 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;
wherein R3 is hydrogen, hydroxy, or —
R10—
O—
R11, wherein R10 is a covalent bond or alkyl, and R11 is C-amido or acyl;
or R3 together with R2 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;
wherein R4 is hydrogen, hydroxy, alkyl, carboxyl, —
R12—
O—
R13, or —
R12-R14, and wherein R12 is a covalent bond or alkyl, and R13 is C-amido or acyl, and R14 is N-amido, —
POR15R16, —
SO2R17, or sulfonamido and wherein R15, R16, R17 are independently alkoxy;
wherein R5 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
wherein R6 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, or aralkoxy;
wherein X1 is —
O—
, —
CO—
, or —
N—
;
wherein X2 is—
O—
, —
N—
, —
CR9—
or —
CO—
, wherein R19 is hydrogen, alkyl, alkenyl, alkynyl;
wherein X4 is —
CR20—
, wherein R20 is hydrogen, alkyl, alkenyl, alkynyl, or hydroxy;
wherein X5 is —
CR21, wherein R21 is hydrogen, alky, alkenyl, alkynyl, or alkoxy;
wherein X6, is —
CR22 wherein R22 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, halogen, or nitro;
wherein X8, is —
CR23, wherein R23 is hydrogen, alkyl, alkenyl, alkynyl, aryl, alkoxy;
wherein X9 is alkyl, alkenyl, alkynyl, ether, secondary or tertiary amino, or sulfanyl;
wherein n is 0, 1, 2, or 3.
1 Assignment
0 Petitions
Accused Products
Abstract
Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders, as well as cancer.
-
Citations
31 Claims
-
1. Compounds according to the formula:
-
wherein R1 is an amido which is NR′
COR″
, and R′
is hydrogen and R″
is aryl or heterocycle;wherein R2 is hydrogen, hydroxy, or —
R8—
OR9, wherein R8 is a covalent bond or alkyl, and R9 is C-amido or acyl;
or R2 together with R3 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;wherein R3 is hydrogen, hydroxy, or —
R10—
O—
R11, wherein R10 is a covalent bond or alkyl, and R11 is C-amido or acyl;
or R3 together with R2 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;wherein R4 is hydrogen, hydroxy, alkyl, carboxyl, —
R12—
O—
R13, or —
R12-R14, and wherein R12 is a covalent bond or alkyl, and R13 is C-amido or acyl, and R14 is N-amido, —
POR15R16, —
SO2R17, or sulfonamido and wherein R15, R16, R17 are independently alkoxy;wherein R5 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; wherein R6 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, or aralkoxy; wherein X1 is —
O—
, —
CO—
, or —
N—
;wherein X2 is—
O—
, —
N—
, —
CR9—
or —
CO—
, wherein R19 is hydrogen, alkyl, alkenyl, alkynyl;wherein X4 is —
CR20—
, wherein R20 is hydrogen, alkyl, alkenyl, alkynyl, or hydroxy;wherein X5 is —
CR21, wherein R21 is hydrogen, alky, alkenyl, alkynyl, or alkoxy;wherein X6, is —
CR22 wherein R22 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, halogen, or nitro;wherein X8, is —
CR23, wherein R23 is hydrogen, alkyl, alkenyl, alkynyl, aryl, alkoxy;wherein X9 is alkyl, alkenyl, alkynyl, ether, secondary or tertiary amino, or sulfanyl; wherein n is 0, 1, 2, or 3. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27)
wherein R1 is an amido which is NR′
COR″
, and R′
is hydrogen and R″
is aryl or heterocycle;wherein R2 is hydrogen or hydroxy; wherein R3 is hydrogen or hydroxy; wherein R4 is hydrogen or methyl; wherein R5 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; wherein R6 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, or aralkoxy; wherein X1 is —
O—
or —
N—
;wherein X2 is —
CR19—
or —
CO—
, wherein R19 is hydrogen, alkyl, alkenyl, alkynyl;wherein X4 is —
CR20—
, wherein R20 is hydrogen, alkyl alkenyl, alkynyl, or hydroxy;wherein X5, is —
CR2, wherein R21 is hydrogen, alkyl, alkenyl, alkynyl;wherein X6, is —
CR22, wherein R22 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, halogen, or nitro;wherein X8, is —
CR23, wherein R23 is hydrogen, alkyl, alkenyl, or alkynyl;wherein X9 is alkyl, alkenyl, alkynyl, ether, or secondary or tertiary amino; and wherein n is 0, 1, 2, or 3.
-
-
3. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is aryl according to;wherein R24 and R25 are independently hydrogen, alkyl, amino, halo, hydroxy, or alkoxy.
- COR″
-
4. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is aryl according to;wherein R24 and R25 are alkoxy.
- COR″
-
5. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and wherein R′
is hydrogen and R″
is aryl according to;wherein R24 and R25 are independently hydrogen, alkyl or alkoxy.
- COR″
-
6. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and wherein R′
is hydrogen and R″
is aryl selected from the group consisting of;N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-6-methoxybiphenyl-3-carboxamide (28); N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-6-methoxy-2′
-methylbiphenyl-3-carboxamide (29);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-6-methoxy-3′
-methylbiphenyl-3-carboxamide (30);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-6-methoxy-4′
-methylbiphenyl-3-carboxamide (31);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-2′
,6-dimethoxybiphenyl-3′
-carboxamide (32);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (33);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-4′
,6-dimethoxybiphenyl-3′
-carboxamide (34);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-2′
-hydroxy-6-methoxybiphenyl-3-carboxamide (35);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-3′
-hydroxy-6-methoxybiphenyl-3-carboxamide (36); andN-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-4′
-hydroxy-6-methoxybiphenyl-3-carboxamide (37).
- COR″
-
7. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and wherein R′
is hydrogen and R″
is aryl according to;wherein X is ether or amino; wherein R24 is alkoxy; wherein R25 is hydrogen, hydroxy, alkoxy, or aryloxy; and wherein R26 is hydrogen, alkoxy, aryloxy, or amino.
- COR″
-
8. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and wherein R′
is hydrogen and R″
is a an indole according to;or a R″
is a pendant aryl according to;
- COR″
-
9. The compounds according to claim 1 which are selected from the group consisting of:
-
N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26a);N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-6-propoxy-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26b);N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-6-isopropoxy-8-methyl-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26c);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-5-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26d);N-(8-benzyl-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26e);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-2-oxo-8-phenyl-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26f);N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methoxy-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26g);N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-ethyl-2-oxo-2H-chromen-3-yl)-3′
,6-dimethoxybiphenyl-3-carboxamide (26h);
-
-
10. The compounds according to claim 1 which are selected from the group consisting of:
-
N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (26i); N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-6-propoxy-2H-chromen-3-yl)-1H-indole-2-carboxamide (26j); N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-6-isopropoxy-8-methyl-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (26k); N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-5-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (26l); N-(8-benzyl-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (26m); N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-2-oxo-8-phenyl-2H-chromen-3-yl)-1H-indole-2-carboxamide (26n); N-(7-((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methoxy-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (26o); and N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-ethyl-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (26p).
-
-
11. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is a heterocycle selected from the group consisting of pyridine, benzofuran, indole, and oxazole.
- COR″
-
12. The compounds according to claim 1:
-
wherein R1 is an amido which is NR′
COR″
, and R′
is hydrogen and R″
is a heterocycle selected from the group consisting of pyridine, benzofuran, and indole; andwherein R2 is hydroxy;
or R2 together with R3 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;wherein R3 is hydroxy, or R3 together with R2 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen; wherein R4 is methyl; wherein R5 is methyl; wherein R6 is methoxy; wherein X1 is —
O—
;wherein X2 is —
CO—
;wherein X4 is —
CR20—
, wherein R20 is hydrogen, alkyl, alkenyl, alkynyl, or hydroxy;wherein X5, is —
CR21, wherein R21 is hydrogen, alkyl, alkenyl, alkynyl;wherein X6, is —
CR22, wherein R22 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, halogen, or nitro;wherein X8, is —
CR23, wherein R23 is hydrogen, alkyl, alkenyl, alkynyl;wherein X9 is ether which is —
O—
;wherein n is 1.
-
-
13. The compounds according to claim 1:
-
wherein R1 is an amido which is NR′
COR″
, and R′
is hydrogen and R″
is a heterocycle selected from the group consisting of pyridine, benzofuran, and indole;wherein R2 is hydroxy; wherein R3 is hydroxy; wherein R4 is methyl; wherein R5 is methyl; wherein R6 is methoxy; wherein X1 is —
O—
or —
N—
;wherein X2 is —
CR19—
or —
CO—
, wherein R19 is hydrogen or alkyl;wherein X4 is —
CR20—
, wherein R20 is hydrogen;wherein X5, is —
CR21, wherein R21 is hydrogen;wherein X6, is —
CR22, wherein R22 is hydrogen;wherein X8, is —
CR23, wherein R23 is hydrogen or alkyl;wherein X9 is ether which is —
O—
; andwherein n is 1.
-
-
14. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is aryl or heterocycle according to;wherein R29 is hydrogen, alkoxy, or amino; and wherein R30 is hydrogen, alkoxy, or aryloxy.
- COR″
-
15. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is aryl or heterocycle according to;wherein R29 is hydrogen, alkoxy, or amino; and wherein R30 is hydrogen, alkoxy, or aryloxy.
- COR″
-
16. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is a heterocycle according to;wherein R27 is hydrogen, hydroxy, alkoxy, or aryloxy; and wherein R28 is hydrogen, alkoxy, aryloxy, or amino.
- COR″
-
17. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is a heterocyle according to;wherein X11 is a covalent bond, alkyl, alkenyl, alkynyl, or —
OCH2—wherein R26 is aryl, amino, or hydroxy.
- COR″
-
18. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is aryl according to one of the following;
- COR″
-
19. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is aryl selected from the group consisting of;N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-2-phenylacetamide (22); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-3-phenylpropanamide (23); Benzyl 7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (24); and N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)cinnamamide (25).
- COR″
-
20. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is a heterocycle according to one of the following;
- COR″
-
21. The compounds according to claim 1 wherein R1 is an amido which is NR′
- COR″
, and R′
is hydrogen and R″
is heterocycle and selected from the group consisting of;N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)picolinamide (40); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)nicotinamide (41); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)isonicotinamide (42); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)benzofuran-2-carboxamide (43); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (46); and N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-1H-indole-3-carboxamide (47).
- COR″
-
22. The compound according to claim 1 which is:
N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-1H-indole-2-carboxamide (46).
-
23. The compounds of claim 1 wherein X1 is —
- O— and
X2 is —
CO—
.
- O— and
-
24. The compounds of claim 1 wherein X1 is —
- CO— and
X2 is —
O—
.
- CO— and
-
25. The compounds of claim 1 wherein R4 and R5 are both hydrogen.
-
27. The compound of claim 1 which is N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-2H-pyran-2-yloxy)quinolin-3-yl)-4-methoxy-3-(3-methoxyphenyl)-benzamide (42b).
-
26. The compounds wherein R4 and R5 are independently hydrogen or methyl, and R6 is hydrogen.
-
28. Compounds according to formula:
-
wherein R26 is hydrogen, alkyl, alkoxy, aryl, amino;
or heterocyclewherein R2 is hydrogen or hydroxy; wherein R3 is hydrogen or hydroxy, wherein R4 is hydrogen, hydroxy, or alkyl; wherein R5 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; wherein R6 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, or aralkoxy; wherein R20 is hydrogen, alkyl, alkenyl, alkynyl, or hydroxy; wherein R21 is hydrogen, alkyl, alkenyl, alkynyl, or alkoxy; wherein R22 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, halogen, or nitro; wherein R23 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or alkoxy. - View Dependent Claims (29, 30, 31)
wherein R3 is hydroxy, wherein R4 is alkyl; wherein R5 is alkyl; wherein R6 is alkoxy; wherein X1 is —
N—
, or CR, wherein CR is hydrogen, hydroxy, alkyl, or alkoxy;wherein R20 is hydrogen; wherein R21 is hydrogen; wherein R22 is hydrogen; and wherein R23 is hydrogen.
-
-
30. Compounds of claim 28 which are selected from the group consisting of:
-
N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)benzamide (8); -(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)biphenyl-2-carboxamide (12); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)biphenyl-3-carboxamide (13); 2-Amino-N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)benzamide (18); 3-Amino-N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)benzamide (19); and 4-Amino-N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)benzamide (20).
-
-
31. Compounds of claim 28 which are selected from the group consisting of:
-
N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-2-methoxybenzamide (9); N-(7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-3-methoxybenzamide (10); and N-(7-((2R,3,R4S,5R)-3,4-Dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-4-methoxybenzamide (11).
-
Specification