×

Novobiocin Analogues

  • US 20090187014A1
  • Filed: 02/20/2009
  • Published: 07/23/2009
  • Est. Priority Date: 11/03/2004
  • Status: Active Grant
First Claim
Patent Images

1. Compounds according to the formula:

  • wherein R1 is an amido which is NR′

    COR″

    , and R′

    is hydrogen and R″

    is aryl or heterocycle;

    wherein R2 is hydrogen, hydroxy, or —

    R8

    OR9, wherein R8 is a covalent bond or alkyl, and R9 is C-amido or acyl;

    or R2 together with R3 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;

    wherein R3 is hydrogen, hydroxy, or —

    R10

    O—

    R11, wherein R10 is a covalent bond or alkyl, and R11 is C-amido or acyl;

    or R3 together with R2 and the atoms to which they are attached form a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen;

    wherein R4 is hydrogen, hydroxy, alkyl, carboxyl, —

    R12

    O—

    R13, or —

    R12-R14, and wherein R12 is a covalent bond or alkyl, and R13 is C-amido or acyl, and R14 is N-amido, —

    POR15R16, —

    SO2R17, or sulfonamido and wherein R15, R16, R17 are independently alkoxy;

    wherein R5 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl;

    wherein R6 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, aryloxy, or aralkoxy;

    wherein X1 is —

    O—

    , —

    CO—

    , or —

    N—

    ;

    wherein X2 is—

    O—

    , —

    N—

    , —

    CR9

    or —

    CO—

    , wherein R19 is hydrogen, alkyl, alkenyl, alkynyl;

    wherein X4 is —

    CR20

    , wherein R20 is hydrogen, alkyl, alkenyl, alkynyl, or hydroxy;

    wherein X5 is —

    CR21, wherein R21 is hydrogen, alky, alkenyl, alkynyl, or alkoxy;

    wherein X6, is —

    CR22 wherein R22 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, halogen, or nitro;

    wherein X8, is —

    CR23, wherein R23 is hydrogen, alkyl, alkenyl, alkynyl, aryl, alkoxy;

    wherein X9 is alkyl, alkenyl, alkynyl, ether, secondary or tertiary amino, or sulfanyl;

    wherein n is 0, 1, 2, or 3.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×