HYDROGELS WITH TAPERED EDGE

• US 20090187130A1
• Filed: 01/12/2009
• Published: 07/23/2009
• Est. Priority Date: 01/18/2008
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Peterson, Donald G., Asmus, Robert A., Popko, Daniel T., Smorch, Terrance M., Heinecke, Steven B., Jacobson, Richard L., Holm, David R.
• Granted Patent: US 9,242,022 B2
• Time in Patent Office: Days
• US Class Current: 602/57
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents

Abstract

An adhesive hydrogel dressing as well as to methods of applying the dressing to a patient is described. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. The adhesive hydrogel pad is formed with at least a portion of the perimeter of the hydrogel pad tapered proximate the area that the hydrogel pad and release liner separate during liner removal.

Claims

1. An island dressing, comprising

a backing that comprises a first major surface;

an adhesive located on the first major surface of the backing;

a hydrogel island pad proximate the first major surface of the backing, wherein the hydrogel pad comprises less than 45% water; and

a release liner;

wherein at least a portion of the perimeter of the hydrogel pad is tapered proximate the area that the hydrogel pad and release liner separate during liner removal.

4. The island dressing of claim 1, wherein the hydrogel pad is attached to the adhesive on the first major surface of the backing.

5. The island dressing of claim 1, wherein the tapered portion of the hydrogel pad has a thickness less than 40 mils.

6. The island dressing of claim 1, further comprising a carrier releasably attached to a second major surface of the backing.

7. The island dressing of claim 1, wherein the hydrogel comprises

a first polymer comprising a cross-linked poly (N-vinyl) lactam;

a swelling agent; and

a second modifying polymer swellable in the swelling agent;

wherein the first polymer forms a pressure sensitive adhesive in the presence of the swelling agent; and

wherein the second modifying polymer and the swelling agent reduce the adhesiveness of the first polymer while at least maintaining the cohesion of the composition.

8. The island dressing of claim 1, wherein the backing comprises a transparent or translucent polymeric film.

9. The island dressing of claim 1, wherein the hydrogel is transparent or translucent.

10. The island dressing of claim 1, further comprising an antimicrobial agent.

11. The island dressing of claim 10, wherein the antimicrobial agent is selected from the group consisting of parachlorometaxylenol;

triclosan;

chlorhexidine and salts thereof, poly hexamethylene biguanide and salts thereof;

iodine;

idodophors;

silver oxide;

silver and its salts;

peroxides;

antibiotics; and

combinations of the foregoing.

12. The island dressing of claim 7 wherein the poly (N-vinyl)lactam is selected from the group consisting of poly N-vinyl-2-pyrrolidone, poly N-vinyl-2-valerolactam, poly N-vinyl-2-caprolactam, and combinations of the foregoing.

13. The island dressing of claim 7 wherein the swelling agent is selected from the group consisting of monohydric alcohols;

polyhydric alcohols;

glycerol;

polyglycerols;

sorbitol;

polyhydric alcohol ethoxylates;

methoxides of polyethylene glycol;

methoxides of polyhydric alcohol ethoxylates; and

combinations of the foregoing.

14. The island dressing of claim 7, wherein the swelling agent is greater than 50% of the total weight of the composition.

15. The island dressing of claim 7, wherein the second modifying polymer comprises a polysaccharide, polysaccharide derivatives, acrylate, acrylate derivatives, cellulose, cellulose derivatives, and combinations thereof.

16. The island dressing of claim 15 wherein the modifying polymer is selected from the group consisting of hydroxypropyl guar;

guar gum;

hydroxyethyl cellulose;

hydroxypropyl cellulose;

hydroxypropyl methylcellulose;

polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with trialkyl ammonium substituted epoxide;

copolymers of hydroxyethyl cellulose and diallyldimethyl ammonium chloride; and

derivatives and combinations of the foregoing.

17. The island dressing of claim 7 wherein:

the first polymer is present in the composition in an amount between 5% and 45% by weight;

the swelling agent is present in an amount of at least 55% by weight; and

the second modifying polymer is present in an amount between 0.1% and 40% by weight.

18. The island dressing of claim 7 wherein first polymer is poly N-vinyl-2-pyrrolidone;

the swelling agent is triglycerol;

the second polymer is selected from the group consisting of hydroxypropyl guar;

guar gum;

hydroxyethyl cellulose;

hydroxypropyl cellulose;

hydroxypropyl methylcellulose;

polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with trialkyl ammonium substituted epoxide;

copolymers of hydroxyethyl cellulose and diallyldimethyl ammonium chloride; and

derivatives and combinations of the foregoing; and

the antimicrobial agent is chlorhexidine gluconate.

2. An island dressing, comprising

a backing that comprises a first major surface;

an adhesive located on the first major surface of the backing;

a hydrogel island pad proximate the first major surface of the backing; and

a release liner;

wherein at least a portion of the perimeter of the hydrogel pad is tapered proximate the area that the hydrogel pad and release liner separate during liner removal; and

wherein the average maximum peel force to initiate separation of an one-inch wide untapered hydrogel pad and a release liner is at least 25% greater than the average maximum peel force of the tapered hydrogel pad and the release liner, when measured by the T-peel Test Method performed after conditioning the island dressing for one week at 50 degrees C.

3. An island dressing, comprising

a backing that comprises a first major surface;

an adhesive located on the first major surface of the backing;

an adhesive hydrogel island pad proximate the first major surface of the backing; and

a release liner;

wherein at least a portion of the perimeter of the hydrogel pad is tapered proximate the area that the hydrogel pad and release liner separate during liner removal.