Iontophoresis Device Controlling Amounts of a Sleep-Inducing Agent and a Stimulant to be Administered and Time at Which the Drugs are Administered

• US 20090187134A1
• Filed: 10/02/2006
• Published: 07/23/2009
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Application Number:
  US11/992,673
• Publication Number:
  US 20090187134A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An iontophoresis device includes an electric power source device, a drug administration device and a current control device. The drug administration device may include at least two or more electrode assemblies each holding an ionic drug. The drug administration device may be coupled to the electric power source device. The current control device may control current flowing to respective ones of the electrode assemblies. An amount of the ionic drug is releasable from each of the electrode assemblies at a defined time when transdermally administered to an organism in accordance with the current flowing from the current control device, wherein at least one of the two or more electrode assemblies holds a sleep-inducing agent as the ionic drug, and at least another one of the two or more electrode assemblies holds a stimulant as the ionic drug.

Claims

1. An iontophoresis device comprising:

an electric power source device;

drug administration device including at least two or more electrode assemblies each holding an ionic drug, the drug administration device coupled to the electric power source device; and

current control device to control current flowing to respective ones of the electrode assemblies,

an amount of the ionic drug is releasable from each of the electrode assemblies at a defined time when transdermally administered to an organism in accordance with the current flowing from the current control device, wherein

at least one of the two or more electrode assemblies holds a sleep-inducing agent as the ionic drug, and at least another one of the two or more electrode assemblies holds a stimulant as the ionic drug.

2. The iontophoresis device according to claim 1, wherein the electrode assemblies of the drug administration device comprises:

two or more first electrode assemblies to respectively hold the ionic drug; and

one or more second electrode assemblies to serve as counter electrodes of the first electrode assemblies.

3. The iontophoresis device according to claim 1, wherein the drug administration device includes at least four or more electrode assemblies having:

a first plurality of first electrode assemblies respectively holding the ionic drug;

a first plurality of second electrode assemblies respectively holding the ionic drug;

a second plurality of second electrode assemblies to serve as counter electrodes of the first plurality of first electrode assemblies; and

a second plurality of first electrode assemblies to serve as counter electrodes of the first plurality of second electrode assemblies.

4. The iontophoresis device according to claim 2, wherein each of the two or more first electrode assemblies comprises:

a first electrode coupled to the electric power source device having same polarity as that of a drug component of the ionic drug in the first electrode assembly;

a first electrolyte solution holding portion to hold an electrolyte solution by being impregnated with the electrolyte solution, the first electrolyte solution holding portion positioned adjacent the first electrode;

a first ion exchange membrane to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane positioned adjacent the electrolyte solution holding portion;

a drug solution holding portion to hold the ionic drug by being impregnated with the ionic drug, the drug solution holding portion positioned adjacent the first ion exchange membrane; and

a second ion exchange membrane to substantially pass ions having a polarity opposite the polarity of the ionic drug and substantially block ions having a polarity that is same as the polarity of the ionic drug, the second ion exchange membrane positioned adjacent the drug solution holding portion.

6. The iontophoresis device according to claim 1, wherein the drug administration device is configured integrally.

7. The iontophoresis device according to claim 1, wherein the current control device comprises:

a load resistor provided between each of the electrode assemblies and the electric power source device;

a current detecting portion to detect a current flowing to the load resistor; and

a feedback control portion to allow a controlled current to flow to each of the electrode assemblies in accordance with an output from the current detecting portion.

9. The iontophoresis device of claim 2, wherein each of the one or more second electrode assemblies comprises:

a second electrode electrically coupled to the electric power source device to have a polarity opposite that of the first electrode in each of the two or more first electrode assemblies;

a second electrolyte solution holding portion to hold an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion positioned adjacent the second electrode; and

a third ion exchange membrane to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the third ion exchange membrane positioned adjacent the second electrolyte solution holding portion.

5. (canceled)

8. A method of operating an iontophoresis device comprising:

providing an electric power source device;

coupling a drug administration device to the electric power source device, the drug administration device including at least two or more electrode assemblies respectively holding a sleep-inducing drug and a stimulant drug;

placing the drug administration device on a skin surface of an organism;

energizing the drug administration device with the electric power source device;

providing a current control device to control current flowing through respective ones of the electrode assemblies; and

releasing a defined amount of the sleep-inducing drug and the stimulant drug at a defined time.