PERITONEAL DIALYSIS SYSTEM

• US 20090187139A1
• Filed: 02/07/2007
• Published: 07/23/2009
• Est. Priority Date: 02/08/2006
• Status: Abandoned Application

• Current Assignee: Debiotech S.A.
• Original Assignee: Debiotech S.A.
• Inventors: Mastalli, Diego, Zunino, Paolo, Quarteroni, Alfio
• Application Number:
  US12/278,662
• Publication Number:
  US 20090187139A1
• Time in Patent Office: Days
• US Class Current: 604/29
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/282 Operational modes
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture

Abstract

Peritoneal dialysis system comprising pumping means, therapy data receiving means and processing means, said processing means being designed to process said therapy data and to impart a switching sequence to said pumping means characterized by the fact that said processing means are furthermore designed to impart a specific exchange profile for each exchange cycle.

Claims

1. Peritoneal dialysis system comprising pumping means, therapy data receiving means and processing means, said processing means being designed to process said therapy data and to impart a switching sequence to said pumping means characterized by the fact that said processing means are furthermore designed to impart a specific exchange profile for each exchange cycle.

2. Peritoneal dialysis system according to claim 1 wherein said processing means are designed to vary the volume of liquid injected in each exchange cycle.

3. Peritoneal dialysis system according to claim 1 wherein said processing means are designed to vary the volume of liquid extracted in each exchange cycle.

4. Peritoneal dialysis system according to claim 1 wherein said processing means are designed to vary the dwell time in each exchange cycle.

5. Peritoneal dialysis system according to claim 1 wherein said therapy data include the total therapy time (T_tot), the total dialysate volume available for the peritonal dialysis session (V_tot), the flow rate of the pumping means (q), the maximum dialysate volume that can be contained in the peritoneal cavity (V_max), the minimum dialysate volume reachable in the peritoneal cavity (V_min) and the number of cycles of the therapy (N).

6. Peritoneal dialysis system according to claim 1 wherein said processing means are capable to determine each dwell time TD(i) according to the following system of equations:

$\{\hspace{1em}<br><br>\begin{array}{c}\mathrm{TD}<br><br>\left(i+1\right)=\left(\mathrm{\alpha <br><br>}+\mathrm{\gamma <br><br>}<br><br><br><br>i\right)<br><br>\mathrm{TD}<br><br>\left(i\right),i=1,\mathrm{\dots <br><br>}<br><br>,N-1\\ \mathrm{TD}<br><br>\left(1\right)=\frac{T_{\mathrm{tot}}-2<br><br>\frac{V_{\mathrm{tot}}}{q}}{1+\underset{j=1}{\overset{N-2}{\sum <br><br>}}<br><br>\underset{i=1}{\overset{j}{\prod <br><br>}}<br><br><br><br>\mathrm{\alpha <br><br>}+\mathrm{\gamma <br><br>}<br><br><br><br>i}\end{array}$

where,

α

is the parameter which fixes a base for the ratio T D(i+1)/T D(i), D is the parameter which allows to change the ratio T D(i+1)/T D(i) with respect the number of the cycle,

TD₍₁₎ is computed to respect the total therapy time T_tot.

7. Peritoneal dialysis system according to claim 1 wherein said processing means are capable to determine each volume injected DV(i) according to the following system of equations:

$\{\hspace{1em}<br><br>\begin{array}{c}\mathrm{DV}<br><br>\left(i+1\right)=\left(\mathrm{\beta <br><br>}+\mathrm{\delta <br><br>}<br><br><br><br>i\right)<br><br>\mathrm{DV}<br><br>\left(i\right),i=1,\mathrm{\dots <br><br>}<br><br>,N-2\\ \mathrm{DV}<br><br>\left(1\right)=\frac{V_{\mathrm{tot}}}{1+\underset{j=1}{\overset{N-2}{\sum <br><br>}}<br><br>\underset{i=1}{\overset{j}{\prod <br><br>}}<br><br><br><br>\mathrm{\beta <br><br>}+\mathrm{\delta <br><br>}<br><br><br><br>i}\end{array}$

where,

β

is the parameter which fix a base for the ratio DV(i+1)=DV (i),

δ

is the parameter which allows to change the ratio DV(i+1)=DV (i) with respect the number of the cycle.

V D(1) is computed to respect the total dialysate volume Vtot available.

8. Peritoneal dialysis system according to claim 1 claims wherein said processing means are designed to determine the switching sequence as follows:

t0=0,

t_k+1=t_k+DT(k);

K=0;

. . . ;

3N+1

where DT(k) represents the time needed in each exchange cycle for the injection phase, the dwell and the extraction phase.

14. Method according to claim 8 wherein each volume injected DV(i) is determined according to the following system of equations:

$\{\hspace{1em}<br><br>\begin{array}{c}\mathrm{DV}<br><br>\left(i+1\right)=\left(\mathrm{\beta <br><br>}+\mathrm{\delta <br><br>}<br><br><br><br>i\right)<br><br>\mathrm{DV}<br><br>\left(i\right),i=1,\mathrm{\dots <br><br>}<br><br>,N-2\\ \mathrm{DV}<br><br>\left(1\right)=\frac{V_{\mathrm{tot}}}{1+\underset{j=1}{\overset{N-2}{\sum <br><br>}}<br><br>\underset{i=1}{\overset{j}{\prod <br><br>}}<br><br><br><br>\mathrm{\beta <br><br>}+\mathrm{\delta <br><br>}<br><br><br><br>i}\end{array}$

where,

β

is the parameter which fix a base for the ratio DV(i+1)=DV (i),

δ

is the parameter which allows to change the ratio DV(i+1)=DV (i) with respect the number of the cycle.

V D(1) is computed to respect the total dialysate volume Vtot available.

9. Method for determining a peritoneal dialysis treatment characterized by the fact that the liquid exchange profile is varying from one exchange cycle to the other.

10. Method according to claim 9 wherein the dwell time TD varies from one exchange cycle to the other.

11. Method according to claim 9 wherein the volume of liquid injected DV varies from one exchange cycle to the other.

12. Method according to claim 9, wherein the volume of liquid extracted DV varies from one exchange cycle to the other.

13. Method according to claim 9 wherein each dwell time TD(i) is determined according to the following system of equations:

$\{\hspace{1em}<br><br>\begin{array}{c}\mathrm{TD}<br><br>\left(i+1\right)=\left(\mathrm{\alpha <br><br>}+\mathrm{\gamma <br><br>}<br><br><br><br>i\right)<br><br>\mathrm{TD}<br><br>\left(i\right),i=1,\mathrm{\dots <br><br>}<br><br>,N-1\\ \mathrm{TD}<br><br>\left(1\right)=\frac{T_{\mathrm{tot}}-2<br><br>\frac{V_{\mathrm{tot}}}{q}}{1+\underset{j=1}{\overset{N-2}{\sum <br><br>}}<br><br>\underset{i=1}{\overset{j}{\prod <br><br>}}<br><br><br><br>\mathrm{\alpha <br><br>}+\mathrm{\gamma <br><br>}<br><br><br><br>i}\end{array}$

where,

α

is the parameter which fixes a base for the ratio T D(i+1)/T D(i), β

is the parameter which allows to change the ratio T D(i+1)/T D(i) with respect the number of the cycle,

TD₍₁₎ is computed to respect the total therapy time T_tot.