INTEGRATED INTRA-DERMAL DELIVERY, DIAGNOSTIC AND COMMUNICATION SYSTEM
First Claim
1. An intra-dermal delivery system comprising:
- at least one micro/nano sized drug delivery device for intra-dermally delivering a drug below the stratum corneum, the drug being stored in a space within the device, the device having an actuator for causing selective movement of at least a portion of the device to deliver the drug below the stratum corneum;
a programmable controller in communication with the at least one device for controlling the actuation of the actuator; and
a biofeedback device that is in communication with the programmable controller and includes at least one biosensor that measures at least one bio-property of the patient,wherein the controller is programmed based on a patient'"'"'s needs to delivery the drug at a prescribed time or based on a signal received from the biofeedback device.
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Accused Products
Abstract
In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.
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Citations
33 Claims
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1. An intra-dermal delivery system comprising:
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at least one micro/nano sized drug delivery device for intra-dermally delivering a drug below the stratum corneum, the drug being stored in a space within the device, the device having an actuator for causing selective movement of at least a portion of the device to deliver the drug below the stratum corneum; a programmable controller in communication with the at least one device for controlling the actuation of the actuator; and a biofeedback device that is in communication with the programmable controller and includes at least one biosensor that measures at least one bio-property of the patient, wherein the controller is programmed based on a patient'"'"'s needs to delivery the drug at a prescribed time or based on a signal received from the biofeedback device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An intradermal system comprising:
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at least one micro/nano sized device that is configured for intradermally delivering a drug below the stratum corneum and for withdrawing a body fluid for testing thereof;
the device having an actuator for causing selective movement of at least a portion of the device to deliver the drug below the stratum corneum or to withdraw the body fluid;a programmable controller in communication with the at least one device for controlling the actuation of the actuator; and a biofeedback device that is in communication with the programmable controller and includes at least one biosensor that measures at least one bio-property of the patient, wherein the biofeedback device is configured to send diagnostic information to the controller independently of drug delivery, wherein the controller is programmed based on a patient'"'"'s needs to delivery the drug at a prescribed time or based on a signal received from the biofeedback device.
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32. An intra-dermal delivery system comprising:
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an array of combined micro/nano sized storage cells and delivery devices, each storage cell containing a drug; a programmable controller that includes an energy source, each of the micro/nano sized storage cell/delivery device combinations being individually linked to the energy source, the controller being configured to be programmed depending upon the patient'"'"'s needs to sequentially fire a prescribed number of the delivery devices over a period of time to delivery the drug at set time intervals and over the period of time; and a biofeedback device that is in communication with the programmable controller and includes at least one bio sensor that measures at lease one bio-property of the patient and sends a signal if the measured bio-property falls outside an acceptable range, thereby resulting in the biofeedback device instructing the programmable controller to actuate the energy source(s) associated with one or more of the combined micro/nano sized storage cells/delivery devices.
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33. An intra-dermal delivery system comprising:
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a cartridge including; a flexible implant device having a substrate and a plurality of supports extending therefrom and a plurality of implant bodies being removably coupled to the supports and designed for implantation in the patient, each implant body including barbs and containing a substance that is to be intra-dermally delivered to the patient; and a protective layer of gel material that can be penetrated by the implant bodies when a sufficient force is applied to the substrate in the direction of the gel layer; and an applicator that has a compartment that receives the cartridge, the applicator having electronics, including a controller, formed on a permanent interface device thereof, the controller being configured to selectively actuate the cartridge for delivering a select number of implants to the patient and advance the implant device so that a fresh number of implant devices are ready for delivery.
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Specification