COMPOSITIONS AND METHODS FOR JOINING NON-CONJOINED LUMENS
First Claim
Patent Images
1. A method for joining at least two non-conjoined lumens in a patient, wherein at least one of the lumens has a clamp to arrest the flow of the fluid therein, which method comprises:
- (a) providing a biocompatible solid mass at least in a distal portion of the lumen having the clamp;
(b) aligning the lumens;
(c) closing the aligned lumens to form a conduit;
(d) inducing a phase change of the biocompatible solid mass from a solid to a flowable liquid;
(e) confirming substantial completion of the phase change; and
(f) removing the clamp thereby establishing flow through the conduit.
1 Assignment
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Accused Products
Abstract
Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient'"'"'s body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
89 Citations
43 Claims
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1. A method for joining at least two non-conjoined lumens in a patient, wherein at least one of the lumens has a clamp to arrest the flow of the fluid therein, which method comprises:
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(a) providing a biocompatible solid mass at least in a distal portion of the lumen having the clamp; (b) aligning the lumens; (c) closing the aligned lumens to form a conduit; (d) inducing a phase change of the biocompatible solid mass from a solid to a flowable liquid; (e) confirming substantial completion of the phase change; and (f) removing the clamp thereby establishing flow through the conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 15, 33, 35, 37, 38, 39, 40, 41, 42)
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9. A method for joining at least two non-conjoined lumens in a patient, which method comprises:
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(a) approximating the lumens in a connecting position; (b) providing a biocompatible phase-reversible sol-gel composition in a gel phase in the distal portion of both lumens; (c) closing the lumens to form a conduit; (d) inducing a phase transition of the sol-gel wherein the sol-gel changes from the gel phase to a liquid phase; and (e) establishing flow through the conduit. - View Dependent Claims (10, 11, 12, 13, 14)
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16. A method for joining at least two non-conjoined lumens in a patient, wherein at least one of the lumens is clamped to arrest the flow of body fluid therein, which method comprises:
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flushing the distal portion of the clamped lumen with a biocompatible liquid; approximating the lumens in a connecting position, which approximating comprises partially suturing the lumens; providing a biocompatible phase-reversible sol-gel composition in a gel phase in the distal portion of both lumens; closing the lumens to form a conduit with a biocompatible adhesive; inducing a phase transition of the sol-gel wherein the sol-gel changes from the gel phase to a liquid phase; confirming substantial completion of the phase transition; and removing the clamps thereby establishing flow through the conduit. - View Dependent Claims (17, 18, 19, 20, 25, 26, 28, 29, 30)
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21-24. -24. (canceled)
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27. (canceled)
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31-32. -32. (canceled)
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34. (canceled)
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36. (canceled)
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43-49. -49. (canceled)
Specification