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Method of Error Reduction in Nucleic Acid Populations

  • US 20090188793A1
  • Filed: 10/23/2007
  • Published: 07/30/2009
  • Est. Priority Date: 02/28/2002
  • Status: Abandoned Application
First Claim
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1. A method for separation of DNA molecules of correct sequence away from DNA molecule of incorrect sequence, the method comprising the steps of(a) exposing a solution of double stranded DNA molecules to a DNA binding agent which will binds selectively to duplex DNA molecules having a sequence mismatch between its duplex strands;

  • and(b) separating the DNA molecules to which the DNA binding agent bound from those DNA molecules to which the DNA binding agent did not bind.

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