Extended treatment of tumors through vessel occlusion with light activated drugs
First Claim
1. A method of treating a subject having a condition susceptible to treatment through occlusion of blood vessels, the treatment comprising:
- a) identifying at least one blood vessel to be occluded;
b) selecting a photosensitizer that occludes blood vessels upon excitation with an appropriate wavelength of radiation;
c) delivering to the subject a dose of the photosensitizer, sufficient to cause vessel occlusion after excitation; and
d) exciting photosensitizer in the vicinity of the blood vessel with an appropriate light wavelength for a sufficient period of time to cause occlusion of the blood vessel.
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Accused Products
Abstract
Methods of treating diseases of a subject through selective occlusion of blood vessels. The methods include identifying and/or mapping the blood vessels supplying nutrients to the diseased or unwanted tissue, delivering an appropriate dose of an occlusion-forming photosensitizer to the subject, and exciting the photosensitizer with sufficient light irradiation in the vicinity of the blood vessels to cause vessel occlusion. The vessel occlusion cuts off nutrient supply to the diseased or unwanted tissue resulting in cell death of that tissue and any other tissue served by the occluded vessels.
26 Citations
19 Claims
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1. A method of treating a subject having a condition susceptible to treatment through occlusion of blood vessels, the treatment comprising:
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a) identifying at least one blood vessel to be occluded; b) selecting a photosensitizer that occludes blood vessels upon excitation with an appropriate wavelength of radiation; c) delivering to the subject a dose of the photosensitizer, sufficient to cause vessel occlusion after excitation; and d) exciting photosensitizer in the vicinity of the blood vessel with an appropriate light wavelength for a sufficient period of time to cause occlusion of the blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of treating diseased tissue in a subject, the treatment comprising:
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a) identifying diseased or unwanted tissue and at least one blood vessel supplying the tissue; b) selecting a photosensitizer that occludes blood vessels upon excitation with an appropriate wavelength of radiation; c) delivering to the subject a therapeutically effective dose of the photosensitizer; and d) exciting the photosensitizer in the vicinity of the blood vessel for a sufficient period of time to cause occlusion of the blood vessel; whereby occlusion of the blood vessel results in beneficial treatment of the diseased or unwanted tissue and cell death of other tissue served by the same blood vessel. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of treating an extended area of a body organ of a subject using photodynamic therapy, the organ containing a plurality of tumors, the method comprising:
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a) identifying the extended area of the organ containing a plurality of tumors, and at least one major blood vessel supplying the extended area and tumors therein; b) selecting a photosensitizer that occludes blood vessels upon excitation with an appropriate wavelength of radiation; c) delivering to the subject a therapeutically effective dose of the photosensitizer; and d) exciting the photosensitizer around the identified major blood vessel for a sufficient period of time to cause occlusion of the identified blood vessel. - View Dependent Claims (16, 17, 18, 19)
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Specification