AUTOMATIC INJECTOR WITH ANTI-CORING NEEDLE

• US 20090192486A1
• Filed: 11/02/2001
• Published: 07/30/2009
• Est. Priority Date: 11/02/2001
• Status: Active Grant

• Current Assignee: Meridian Medical Technologies Incorporated
• Original Assignee: Meridian Medical Technologies Incorporated
• Inventors: Hill, Robert L., Cain, Seth P., Whittier, John, Mesa, C. Michael, Wilmot, John G.
• Granted Patent: US 7,569,035 B1
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/2086 having piston damping means, e.g. axially or rotationally acting retarders
• CPC Class Codes: A61M 2005/3151 by friction
• CPC Class Codes: A61M 2205/192 Avoiding coring, e.g. preventing formation of particles during puncture
• CPC Class Codes: A61M 2205/195 by the needle tip shape
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3286 Needle tip design, e.g. for improved penetration
• CPC Class Codes: A61M 5/3291 Shafts with additional lateral openings

Abstract

In one embodiment, an automatic injector comprises a cartridge adapted to contain a charge of medicament, a seal structure disposed toward a forward end of the cartridge, a plunger normally disposed in a generally rearward end of the cartridge and movable through the cartridge toward a generally forward end thereof in response to an actuating procedure. The movable plunger rearwardly confines the medicament within the cartridge. A needle normally disposed in communication with the medicament container provides a passage in which the medicament is released into an individual'"'"'s flesh in response to an actuating procedure projecting the needle into the flesh of the individual. The cartridge having an increased friction region so as to slow the motion of the plunger when the forward end of the needle travels through the seal in order to eliminate coring.

Claims

1. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure, said needle comprising;

a hollow rigid tubing having a cylindrical wall, the cylindrical wall having an inner surface and outer surface;

a lumen opening having a front pointed portion comprising a lancet shaped tip having a facet grinding at an angle, said tip bent in a curve directed toward a longitudinal axis of said cylindrical wall so as to shield the entire cross section of said lumen opening, said cross section of said lumen opening perpendicular to a longitudinal axis of said hollow rigid tubing, said tip comprising primary and secondary facets, said secondary facets ground at an angle at the inner surface of the needle; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

2. The automatic injector as claimed in claim 1, wherein said seal structure seals a forward end of said cartridge.

3. The automatic injector as claimed in claim 1, wherein said friction area comprises a narrowed diameter portion in a wall of said cartridge.

4. The automatic injector as claimed in claim 1, wherein said friction area is a corrugated portion in a wall of said cartridge.

5. The automatic injector as claimed in claim 1, wherein a tip of said needle is coated with polyparaxylylene.

6. The automatic injector as claimed in claim 5, wherein said polyparaxylylene coating has a thickness between about 0.0001 to 0.001 inches.

7. The automatic injector as claimed in claim 1, wherein said needle is normally stored within said cartridge, in contact with said medicament.

10. The automatic injector as claimed in claim 1, wherein said secondary facets are also ground at an angle at the outside surface of the needle.

11. The automatic injector as claimed in claim 1, wherein said plunger comprises a material selected from the group of plastics and rubbers.

12. The automatic injector as claimed in claim 3, wherein said plunger comprises ribs arranged to reduce the rate of acceleration of said needle when in contact with said friction region.

13. The automatic injector as claimed in claim 4, wherein said plunger comprises ribs arranged to reduce the rate of acceleration of said needle when in contact with said friction region.

14. The automatic injector as claimed in claim 11, wherein said plunger comprises a plurality of materials having different ductilities, said materials are selected to interact differently with said friction area to reduce the rate of acceleration of said needle.

15. The automatic injector as claimed in claim 1, wherein said releasable energy source comprises a normally compressed spring which is released in response to said predetermined actuating procedure.

16. The automatic injector as claimed in claim 1, wherein said spring having a spring constant between 1.5 lb/in and 6.5 lb/in.

17. The automatic injector as claimed in claim 1, wherein said seal structure comprises a material selected from the group of plastics and rubber.

8. (canceled)

9. (canceled)

18. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

wherein said needle comprises a damping structure for reducing the rate of acceleration of said needle by the viscous resistance created when said damping structure moves within said medicament; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

19. The automatic injector as claimed in claim 18, wherein said damping structure comprises a damping disk attached to said needle and arranged to reduce the rate of acceleration of said needle by the flow resistance created when said disk moves through said medicament.

20. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament with said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

said needle comprising;

a hollow rigid tubing having a cylindrical wall defining a longitudinal passage therethrough, said cylindrical wall including opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip, said forward tip portion being bent in a manner to shield the entire cross-section of said longitudinal passage, said cross section of said longitudinal passage perpendicular to a longitudinal axis of said hollow rigid tubing; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

21. The automatic injector as claimed in claim 20, wherein said seal structure seals a forward end of said cartridge.

22. The automatic injector as claimed in claim 20, wherein the tip of said needle is coated with polyparaxylylene.

23. The automatic injector as claimed in claim 22, wherein said polyparaxylylene coating has a thickness between about 0.0001 to 0.001 inches.

24. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

said needle comprising;

a hollow rigid tubing having a cylindrical wall defining a longitudinal passage therethrough, said cylindrical wall including opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip, said forward tip portion being bent in a manner to shield the entire cross-section of said longitudinal passage, said cross section of said longitudinal passage perpendicular to a longitudinal axis of said needle;

wherein said forward tip portion is bent at an angle approximately between 51 degrees and 100 degrees;

said angle being defined as the angle between a tangent to a curvature of an outer surface at said end tip and the longitudinal axis of said needle; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

25. The automatic injector as claimed in claim 24, wherein said seal structure seals a forward end of said cartridge.

26. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

said needle comprising;

a hollow rigid tubing having a cylindrical wall defining a longitudinal passage therethrough, said cylindrical wall including opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip, said forward tip portion having a back ground lancet wherein back grinds of said lancet are ground at an angle of about 120 degrees measured in relation to a base line extending transversely across the forward tip portion, the forward tip portion being bent at an angle approximately between 51 degrees and 100 degrees;

said angle being defined as the angle between a tangent to a curvature of an outer surface at said end tip and a longitudinal axis of said needle;

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

27. The automatic injector as claimed in claim 26, wherein said seal structure seals a forward end of said cartridge.

28. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

said needle comprising;

a hollow rigid tubing having a cylindrical wall defining a linear longitudinal passage entirely there through, said cylindrical wall including opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip, said forward tip portion being bent in a manner to shield the entire cross-section of said longitudinal passage, said cross section of said longitudinal passage perpendicular to a longitudinal axis of said hollow rigid tubing;

said needle comprising an enlarged rearward portion constructed and arranged for engagement with said plunger; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

29. The automatic injector as claimed in claim 28, wherein said seal structure seals a forward end of said cartridge.

30. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said carriage;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

said needle comprising;

a hollow rigid tubing having a cylindrical wall defining a linear longitudinal passage entirely there through, said cylindrical wall forming the boundary of the linear longitudinal passage, said cylindrical wall including opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip;

said forward tip portion is bent at an angle approximately between 51 degrees and 100 degrees;

said angle being defined as the angle between a tangent to a curvature of an outer surface at said end tip and a longitudinal axis of said needle;

wherein said needle comprises an enlarged rearward portion constructed and arranged for engagement with said plunger;

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

31. The automatic injector as claimed in claim 30, wherein said seal structure seals a forward end of said cartridge.

32. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge;

a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure;

said needle comprising;

a hollow rigid tubing having a cylindrical wall defining a longitudinal passage extending there through, said cylindrical wall having an inner surface and including opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip, said forward tip portion being bent;

an enlarged rearward portion constructed and arranged for engagement with said plunger, and

a lumen opening having a front pointed portion comprising a lancet shaped tip having a facet grinding at an angle, said forward tip bent in a curve directed toward a longitudinal axis of said cylindrical wall so as to constitute a shield to said lumen opening, said tip comprising primary and symmetrical secondary and tertiary facets, said secondary and tertiary facets each ground at the outside surface of the needle at an angle ranging from 120 degrees to 130 degrees measured in relation to a base line extending transversely across the forward tip portion; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual.

33. The automatic injector as claimed in claim 32, wherein said seal structure seals a forward end of said cartridge.

34. An automatic injector comprising:

a housing having a rearward end and a forward end;

a seal structure disposed toward the forward end of said housing;

a cartridge contained within said housing;

a charge of medicament contained in said cartridge;

a plunger normally disposed in a generally rearward end of said cartridge and movable through said cartridge toward a generally forward end thereof in response to an actuating procedure;

a needle normally disposed within said housing, and projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle in response to said predetermined actuating procedure, said needle comprising;

a hollow rigid tubing having a cylindrical wall that includes opposing first and second wall portions, said first wall portion having a forward tip portion terminating in a forward end tip, said second wall portion terminating at a position rearwardly spaced from said end tip, said forward end tip portion having a back ground lancet wherein back grinds of said forward end tip portion are at an angle ranging from 120 degrees to 130 degrees in relation to a base line extending transversely across the forward tip portion; and

a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge to expel said medicament through said needle and into the flesh of an individual.

35. A method for injecting a medicament with an automatic injector, which injector comprises a housing, a seal structure disposed toward a forward end of said housing, a cartridge contained within said housing, a charge of medicament contained in said cartridge, a plunger movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, said movable plunger rearwardly confining said medicament within said cartridge, a needle normally disposed within said housing, said needle being projectable from the forward end of said housing through said seal structure, said needle being communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through said needle and into the flesh of an individual in response to said predetermined actuating procedure, a releasable energy source releasable in response to said predetermined actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge in sealed relation to expel said medicament through said needle and into the flesh of an individual;

said method comprising;

releasing said energy source;

accelerating said needle forwardly within said housing;

reducing the rate of acceleration of said needle prior to said needle penetrating said seal; and

expelling said medicament through said needle.

36. The method for injecting a medicament with an automatic injector as recited in claim 35, wherein said penetrating said seal is performed at a speed between 250 inches/s and 680 inches/s.

37. The method for injecting a medicament with an automatic injector as recited in claim 35, further comprising:

speeding up said needle after said needle has fully penetrated said seal.

38. A method of injecting a medicament with an automatic injector, the injector comprising a housing, a seal structure disposed toward a forward end of said housing, a cartridge contained within said housing, a charge of medicament contained in said cartridge, a plunger movable through said cartridge toward a generally forward end thereof in response to an actuating procedure, a needle disposed within said housing and having a linear longitudinal passage entirely through the needle, said needle projectable from the forward end of said housing through said seal structure, said needle communicable with said medicament so that movement of said plunger through said cartridge forces said medicament through the longitudinal passage of said needle in response to said actuating procedure, a releasable energy source responsive to said actuating procedure to project said needle from the forward end of the housing and slidingly drive said plunger through said cartridge to expel said medicament through said needle;

said method comprising;

releasing said energy source;

forcing said medicament through said linear longitudinal passage of said needle;

moving said needle forwardly within said housing at a speed of less than 680 inches/s as said needle penetrates said seal structure;

penetrating said seal structure with said needle having a forward tip portion bent so as to shield the entire cross-section of the longitudinal passage, said cross section of the longitudinal passage perpendicular to a longitudinal axis of said needle; and

expelling said medicament through said needle.

39. The method as recited in claim 38, wherein said moving said needle forwardly within said housing comprises moving said needle at a speed of more than 150 inches/s as said needle penetrates said seal structure.