EDIBLE FILM-STRIPS FOR IMMEDIATE RELEASE OF ACTIVE INGREDIENTS

• US 20090196907A1
• Filed: 01/28/2009
• Published: 08/06/2009
• Est. Priority Date: 01/31/2008
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Consumer Inc. (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Consumer Inc. (Johnson & Johnson)
• Inventors: Bunick, Frank J., Wynn, David W., Lee, Der-Yang
• Application Number:
  US12/361,144
• Publication Number:
  US 20090196907A1
• Time in Patent Office: Days
• US Class Current: 424/439
• CPC Class Codes: A61K 47/585 Ion exchange resins, e.g. polystyrene sulfonic acid resin
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence

Abstract

The present invention is directed to an edible film that contains two or more segmented portions and comprises an active ingredient that is distributed on a segmented portion or portions which comprise less than 50% of the cross sectional surface area of a major face of said film. The present invention also relates to methods of treatment for the treatment of various conditions and for taste-masking of pharmaceutical ingredients.

Claims

1. An edible film-strip comprising two or more segmented portions, a therapeutic active ingredient that is distributed on at least one of the segmented portions.

2. An edible film strip of claim 1 wherein the active is present in less than 50% of the total cross sectional surface area of a major face of said film.

3. An edible film strip of claim 1 wherein a segmented portion comprises, within a part of said segmented portion of a length of at least 2 millimeters to a maximum of at least 6 millimeters, a concentration of active ingredient which is 10 percent greater by weight of total active than in a separate part equal in length from a separate portion of the film.

4. An edible film-strip according to claim 1 wherein one or more segmented portions of the film is substantially free of active ingredient.

6. The edible film-strip of claim 1 wherein the film is tapered such that the second portion has a width on its major face that is less than 90% of the width of the first portion of its major face.

23. A method of reducing the bitterness of at least one active ingredient using the edible film of claim 1.

5. An edible film-strip comprising first and second portions and first and second active ingredients wherein the first active ingredient has a higher bitterness level than the second active ingredient and is contained only on the first portion of the edible film-strip and the second active ingredient is contained only on the second portion of the edible film-strip.

7. A method of delivering a topical analgesic or topical anesthetic to the throat using an edible film comprising ingesting an edible film-strip comprising two or more segmented portions, a topical analgesic or topical anesthetic that is distributed on one of the segmented portions, wherein less than 50% of the cross sectional surface area of a major face of said film comprises the topical analgesic or topical anesthetic.

9. The method of claim 7 wherein the topical anesthetic is selected from the group consisting of menthol, dyclonine, phenol, benzocaine, benzyl alcohol, hexylresorcinol and combinations thereof

10. The method of claim 7 wherein the topical analgesic is selected from the group consisting of ibuprofen, ketoprofen, acetaminophen, naproxen, diclofenac and combinations thereof.

11. The method of claim 7 wherein the topical anesthetic is used to treat pharnyngitis.

12. The method of claim 7 wherein the portion of the edible film not containing a topical anesthetic comprises a second active ingredient.

8. A method of delivering a topical analgesic or topical anesthetic to the throat using an edible film comprising ingesting an edible film-strip comprising two or more segmented portions, a topical analgesic or topical anesthetic that is distributed on one of the segmented portions, wherein one segmented portion comprises, within a part of said segmented portion, of a length of at least 2 millimeters to a maximum of about 6 millimeters, a concentration of topical analgesic or topical anesthetic which is 10 percent greater by weight of total active than a separate part equal in length from a separate portion of the film.

13. A method of delivering a topical soothing agent to the throat using an edible film using an edible film comprising ingesting an edible film-strip comprising two or more segmented portions, a topical soothing agent that is distributed on one of the segmented portions, wherein less than 50% of the cross sectional surface area of a major face of said film comprises the topical soothing agent.

14. A method of claim 13 wherein the topical soothing agent is pectin.

15. An edible film-strip comprising a first portion and a second portion and at least different two pharmaceutically active ingredients, wherein the first pharmaceutically active ingredient is contained on the first portion that provides an immediate release portion of the first pharmaceutically active ingredient in a dissolution medium and the second active ingredient is contained on the second portion that provides a modified release of the second pharmaceutically active ingredient in a dissolution medium, wherein the second portion detaches from the first portion upon ingestion.

16. The edible film-strip of claim 15 wherein the film is tapered such that the second portion has a width on its major face that is less than 90% of the width of the first portion of its major face.

17. An edible bilayer film-strip, wherein the second layer comprises a therapeutic active ingredient.

18. An edible bilayer film-strip of claim 17, wherein the first layer is substantially free of a therapeutic active ingredient.

19. An edible bilayer film of claim 17 wherein the first layer and the second layer comprise the same active ingredient, but the second layer comprises a different amount of active ingredient than the amount in the first layer.

21. An edible film of claim 18 wherein the liquid filled beads are substantially free of therapeutic active ingredient.

22. An edible film of claim 18 wherein the film comprises a first active ingredient and wherein the microgel beads comprise a second active ingredient.

20. An edible film comprising a first therapeutic active ingredient and microgel liquid filled beads.