NANO-STRUCTURED THIXOTROPIC INORGANIC PEELING GELS

• US 20090196926A1
• Filed: 01/24/2006
• Published: 08/06/2009
• Est. Priority Date: 01/24/2005
• Status: Active Grant

• Current Assignee: MBS SRL (Moody's Corporation), MSB S.r.l.
• Original Assignee: MBS SRL (Moody's Corporation)
• Inventors: DE ROSA, Mario
• Granted Patent: US 8,951,559 B2
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 5/006 Antidandruff preparations

Abstract

A composition, a method, and a kit are provided for chemical skin peeling, based on nano-structured thixotropic inorganic gels, which have a higher potency and are less irritant of the conventional peeling formulations. The gels of the invention can easily be applied on the skin, where they form a stable, uniform layer, that doesn'"'"'t strain. The kit comprises by a defatting gel, different types of peeling gels and a neutralizing gel. The defatting gel is characterized by a markedly enhanced defatting capacity in comparison to the conventional products, because the sebum solubilized by the solvent is strongly adsorbed on the huge surface of the nano-structured material of the gel. The peeling gels are based on conventional peeling compounds, such as glycolic acid, trichloroacetic acid, pyruvic acid, salicylic acid, Jessner solution, but the presence of nano-structured material strongly increases the peeling effect, allowing the use of lower concentrations of peeling compound, with only minimal skin irritation for the user. The neutralizing gel is characterized by a colour change that allows the operator to verify in real time the neutralization of the peeling agent on the treated skin surface. All the gels of the invention can be easily removed from the skin after the treatment. The thixotropic gels of the invention can be used in chemical skin peeling for the treatment of various cosmetic conditions and dermatological disorders, including dry skin, acne, dandruff, keratoses, age spots, wrinkles and disturbed keratinisation.

Claims

1. A kit for skin peeling comprising:

a) a defatting or detergent thixotropic gel consisting of organic solvents and/or amphiphilic or apolar surfactant;

b) a peeling thixotropic gel comprising a peeling agent;

c) a neutralizing thixotropic gel consisting of a solution of an alkali carbonate or bicarbonate and a pH indicator having a pKi ranging from 2 to 8.

2. A kit according to claim 1 wherein the thixotropic gels a), b) and c) comprise a nano-structured inorganic matrix.

3. A kit according to claim 2 wherein the nano-structured inorganic matrix is silica, aluminium dioxide or titanium dioxide.

4. A kit according to claim 3 wherein the nano-structured inorganic matrix is silica.

5. A kit according to claim 4 wherein the nano-structured inorganic matrix is fumed silica having a density of 0.1 g/ml, average particle size from 70 to 40 nm and a surface from 400 to 50 m²/g.

6. A kit according to claim 1 wherein the kit comprises a defatting gel containing a solvent selected from acetone, alcohols, ethers.

7. A kit according to claim 6, wherein the solvent is acetone, ethanol, butandiol or mixtures thereof.

8. A kit according to claim 6 wherein the nano-structured inorganic matrix is hydrophobic.

9. A kit according to claim 1 wherein the kit comprises a detergent gel containing a amphiphilic or apolar surfactant and the nano-structured inorganic matrix is hydrophilic.

10. A kit according to claim 1 wherein the peeling agent is selected from glycolic acid, citric acid, glucuronic acid, alfa-idroxybutyric acid, lactic acid, malic acid, mandelic acid, mucic acid, pyruvic acid, galacturonic acid, beta-phenyl-lactic acid, beta-phenyl pyruvic acid, beta-idroxybutyrric acid, saccharic acid, tartaric acid, tartronic acid, glucuronolactone, gluconolactone, trichloroacetic acid.

11. A kit according to claim 10 wherein the nano-structured inorganic matrix is hydrophilic.

12. A kit according to claim 1 wherein the peeling agent is resveratrol, resorcinol, phenol, salicylic acid, Jessner solution, methyl pyruvate, ethyl pyruvate.

13. A kit according to claim 12 wherein the nano-structured inorganic matrix is hydrophobic.

14. A kit according to claim 13 wherein the nano-structured inorganic matrix is silica having dimethylsilyl and trimethylsilyl groups.

15. A kit according to claim 1 wherein the nano-structured inorganic matrix is present in the gels a), b) or c) in amounts from 1 to 30% w/w.

16. A kit according to claim 15 wherein the gel a) comprises from 1 to 20% of a surfactant in addition to de-sensitizing and lenitive agents.

17. A kit according to claim 15 wherein the gel b) contains from 70 to 99% of an aqueous or organic solution of the peeling agent.

18. A kit according to claim 1 wherein the neutralizing gel comprises phenol red, sodium bicarbonate and propylene glycol.

19. The use of the kit of claim 1 for the treatment of dry skin, acne, dandruff, keratoses, age spots, wrinkles and disturbed keratinisation.