ADIPONECTIN FOR TREATMENT OF VARIOUS DISORDERS

• US 20090197806A1
• Filed: 01/09/2007
• Published: 08/06/2009
• Est. Priority Date: 01/09/2006
• Status: Active Grant

• Current Assignee: Children's Hospital & Medical Center, University Of Massachusetts
• Original Assignee: University Of Massachusetts
• Inventors: Martin, Lisa J., Newburg, David S., Morrow, Ardythe L.
• Granted Patent: US 8,314,061 B2
• Time in Patent Office: Days
• US Class Current: 514/1.1
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/2264 Obesity-gene products, e.g. leptin
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: G01N 2800/042 Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
• CPC Class Codes: G01N 2800/044 Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
• CPC Class Codes: G01N 2800/065 Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
• CPC Class Codes: G01N 2800/067 Pancreatitis or colitis
• CPC Class Codes: G01N 2800/32 Cardiovascular disorders
• CPC Class Codes: G01N 2800/321 Arterial hypertension
• CPC Class Codes: G01N 2800/323 Arteriosclerosis, Stenosis
• CPC Class Codes: G01N 2800/324 Coronary artery diseases, e.g. angina pectoris, myocardial infarction

Abstract

Methods for treating various disorders by orally administering adiponectin or a biologically active fragment thereof are described.

Claims

1. A method for treating or reducing the risk of obesity in a patient comprising orally administering a composition comprising purified adiponectin or a biologically active fragment thereof.

5. The method of claim 1 wherein the patient is less than 18 years old.

6. The method of claim 1 wherein the patient is less than 15 years old.

7. The method of claim 1 wherein the patient is less than 10 years old.

8. The method claim 1 wherein the patient is less than 1 year-old.

10. The method of any of claim 1 wherein the adiponectin or a biologically active fragment thereof is glycosylated.

11. The method of claim 10 wherein the adiponectin or a biologically active fragment thereof is hydroxylated and glycosylated.

12. The method of claim 10 wherein at least one amino acid of the adiponectin is substituted with a glucosylgalactosyl residue.

2. A method of treating or reducing the risk of metabolic syndrome in a patient comprising orally administering a composition comprising purified adiponectin or a biologically active fragment thereof.

3. A method of treating or reducing the risk of a disorder selected from inflammatory bowel disease, hyperglycemia, insulin resistance, metabolic syndromes associated with insulin resistance, Type 2 diabetes mellitus, metabolic syndromes including hypertension, artherosclerosis, coronary heart disease or ischemic heart disease in a patient comprising orally administering a composition comprising purified adiponectin or a biologically active fragment thereof.

4. A method of treating or reducing the risk of necrotizing enterocolitis in an infant comprising orally administering a composition comprising purified adiponectin or a biologically active fragment thereof.

9. The method of claim 4 wherein the infant was born prematurely.

13-31. -31. (canceled)