Compositions and Methods for Improving Cardiovascular Health

• US 20090197820A1
• Filed: 01/31/2008
• Published: 08/06/2009
• Est. Priority Date: 01/31/2008
• Status: Active Grant

• Current Assignee: Energy Light, LLC
• Original Assignee: HealthSpan Solutions, LLC
• Inventors: Wolfe, Robert, Troup, John, Deutz, Nicolaas ("Mick")
• Granted Patent: US 8,716,249 B2
• Time in Patent Office: Days
• US Class Current: 514/23
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Compositions and methods for improving cardiovascular health in the elderly by delivering a selection of essential amino acids, phytosterols, stanols, and isoflavones, which may be supplemented with a low glycemic carbohydrate and/or a medium chain fatty acid.

Claims

1. A composition of matter for improving cardiovascular health comprising amino acids, a phytostenol, a stanol, and a isoflavone;

wherein said amino acids are selected from the group of histidine, isoleucine, leucine, valine, lysine, methionine, phenylalanine, threonine, arginine, and citrullene.

2. The composition of claim 1 further comprising a low glycemic carbohydrate.

3. The composition of claim 1 further comprising a medium chain fatty acid.

4. The composition of claim 1 wherein said amino acids have a combined mass of about 11 grams;

and

wherein said amino acids further comprise about 0.36 g histidine, about 0.94 g isoleucine, about 3.95 g leucine, about 1.88 g lysine, about 0.39 g methionine, about 0.51 g phenylalanine, about 1.05 g threonine, about 0.82 g valine, and about 1.10 g arginine.

5. The composition of claim 4 wherein said phytostenol and said stanol are in a balanced ratio.

6. The composition of claim 4 wherein said isoflavone has a combined mass of about 30 to about 40 g.

7. The composition of claim 4 further comprising a low glycemic carbohydrate, wherein said low glycemic carbohydrate has a combined mass of about 0.01 to about 15 g.

8. The composition of claim 4 further comprising a medium chain fatty acid, wherein said medium chain fatty acid has a combined mass of about 0.01 to about 15 g.

9. The composition of claim 1 further comprising supplemental minerals.

10. The composition of claim 1 further comprising vitamins.

11. The composition of claim 1 further comprising an excipient.

12. A method of improving cardiovascular health comprising:

having a patient; and

delivering to said patient a composition of matter for improving cardiovascular health comprising amino acids, a phytostenol, a stanol, and a isoflavone;

wherein said amino acids are selected from the group of histidine, isoleucine, leucine, valine, lysine, methionine, phenylalanine, threonine, arginine, and citrullene.

13. The method of claim 12 wherein said composition further comprises a low glycemic carbohydrate.

14. The method of claim 12 wherein said composition further comprises a medium chain fatty acid.

15. The method of claim 12 wherein said amino acids have a combined mass of about 11 grams;

and

wherein said amino acids further comprise about 0.36 g histidine, about 0.94 g isoleucine, about 3.95 g leucine, about 1.88 g lysine, about 0.39 g methionine, about 0.51 g phenylalanine, about 1.05 g threonine, about 0.82 g valine, and about 1.10 g arginine.

16. The method of claim 15 wherein said phytostenol and said stanol are in a balanced ratio.

17. The method of claim 15 wherein said isoflavone has a combined mass of about 30 to about 40 g.

18. The method of claim 12 wherein said delivering further comprises delivering said composition orally to said patient twice daily.

19. The method of claim 12 wherein said patient is over sixty-five years of age.

20. A method of increasing muscle mass, strength, and functional performance, comprising:

having a patient; and

delivering to said patient means for improving cardiovascular health by delivering amino acids, a phytostenol, a stanol, and a isoflavone;

wherein said amino acids are selected from the group of histidine, isoleucine, leucine, valine, lysine, methionine, phenylalanine, threonine, arginine, and citrullene.

21. The method of claim 20 wherein said delivering further comprises delivering a low glycemic carbohydrate.

22. The method of claim 20 wherein said delivering further comprises delivering a medium chain fatty acid.

23. The method of claim 20 wherein said delivering is oral.

24. The method of claim 20 wherein said patient is over sixty-five years of age.