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NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE

  • US 20090197825A1
  • Filed: 11/26/2008
  • Published: 08/06/2009
  • Est. Priority Date: 11/27/2007
  • Status: Active Grant
First Claim
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1. A compound of formula (III), or a metabolite, pharmaceutically acceptable salt, solvate, ester, tautomer or prodrug thereof:

  • whereinX is CH or N;

    W is O, S, S(O), S(O)2, NH, N (optionally substituted alkyl), NC(O) (optionally substituted alkyl) or CH2;

    R1 is H, Cl, Br, I, NH2, methyl, ethyl, n-propyl, i-propyl, optionally substituted methyl, optionally substituted ethyl, optionally substituted n-propyl, optionally substituted i-propyl, CF3, CHF2 or CH2F;

    R3 and R3′

    are independently selected from H and lower alkyl, or R3 and R3′

    together with the carbon to which they are attached form a 4-, 5-, or 6-membered ring, optionally containing 1 or 2 heteroatoms selected from N, S and O;

    R2 is selected from the group consisting of (a), (b), (c) and (d);

    wherein represents a carbon-carbon single bond or a carbon-carbon double bond;

    Q and Q′

    are independently selected from N and CH;

    RP is methyl, ethyl, propyl, i-propyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cyclopropylmethyl;

    R8, R9 and R10 are independently selected from H, F, Cl, Br, CH3, CF3, CFH2, CF2H, ethyl, i-propyl, cyclopropyl, methoxy, OH, OCF3, NH2 and NHCH3;

    R11 is Cl, Br, I, CH3, CF3, methoxy, i-propyl, cyclopropyl, tert-butyl, cyclobutyl or methyl; and

    R12, R13, R14 and R15 are independently H or methyl.

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