MEASUREMENT OF PATIENT PHYSIOLOGICAL PARAMETERS
First Claim
1. A method of determining a physiological parameter of a patient, comprising:
- implanting a plurality of electrodes proximate a blood vessel of the patient;
applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter;
obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter;
calculating vascular impedance based on the measurement signal and the resultant signal; and
calculating a physiological parameter based on the vascular impedance.
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Accused Products
Abstract
A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.
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Citations
25 Claims
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1. A method of determining a physiological parameter of a patient, comprising:
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implanting a plurality of electrodes proximate a blood vessel of the patient; applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter; obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter; calculating vascular impedance based on the measurement signal and the resultant signal; and calculating a physiological parameter based on the vascular impedance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system, comprising:
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at least one pair of measurement electrodes adapted to be implanted proximate a blood vessel of a patient; a controller communicably coupled to the electrodes, the controller configured to calculate the impedance of the blood vessel based on a measured signal from the electrodes, and determine a physiological parameter of a patient based on the calculated impedance. - View Dependent Claims (10, 11, 12, 13)
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14. An implantable baroreflex therapy system for providing real-time feedback of physiological parameters comprising:
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an implantable baroreflex modulation device including one or more therapy electrodes positioned proximate a blood vessel; and a control system operably coupled to the baroreflex modulation device, the control system configured to transmit a therapy signal having a known parameter to the baroreflex modulation device, wherein the one or more therapy electrodes are configured to monitor a resultant signal indicative of a parameter that correlates to the known parameter of the therapy signal, the control system being configured to calculate the impedance of the blood vessel based on the known parameter and the resultant parameter, determine one or more patient physiological parameters based on the calculated impedance, and modify the therapy signal based on the one or more patient physiological parameters. - View Dependent Claims (15, 16, 17, 18, 19)
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20. A method of providing therapy having real-time feedback, comprising:
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implanting a baroreflex modulation device including one or more therapy electrodes on or about a blood vessel; implanting one or more measurement electrodes; transmitting a therapy signal from a control system to the baroreflex modulation device, the therapy signal having at least one known parameter; monitoring a resultant signal with one or more measurement electrodes, the resultant signal having a resultant parameter; calculating the impedance of the blood vessel based on the known parameter and the resultant parameter; determining one or more physiological parameters based on the impedance of the blood vessel; and adjusting the therapy signal based on the one or more physiological parameters. - View Dependent Claims (21, 22, 23)
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24. A method, comprising:
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providing a baroreflex modulation device including one or more electrodes; providing a control system operably coupled to the baroreflex modulation device; and providing instructions recorded on a tangible medium on how to provide real-time feedback of a physiological parameter of a patient undergoing baroreflex therapy, the instructions including; implanting the baroreflex modulation device on or about a blood vessel; delivering a therapy signal having a known parameter to the one or more electrodes of the baroreflex modulation device; monitoring with the measurement electrodes a resultant signal having a resultant parameter as the therapy signal is being delivered; calculating with the control system an impedance of the blood vessel based on the known parameter and the resultant parameter; determining one or more patient parameters based on the calculated impedance; and modifying the therapy signal based on the one or more patient parameters.
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25. A kit for a baroreflex therapy system, comprising:
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a baroreflex modulation device including one or more electrodes; a control system operably coupleable to the baroreflex modulation device; and instructions recorded on a tangible medium for operating the system so as to provide real-time feedback of a physiological parameter of a patient undergoing baroreflex therapy, the instructions including; instructions to program the control system to deliver a therapy signal having a known parameter to the patient through the one or more electrodes of the baroreflex modulation device and to cause the control system to monitor with the one or more electrodes a resultant signal having a resultant parameter, determining one or more patient parameters based on the calculated impedance, and modifying the therapy signal based on the one or more patient parameters.
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Specification