ORAL CARE PRODUCT AND METHODS OF USE AND MANUFACTURE THEREOF

• US 20090202450A1
• Filed: 03/28/2008
• Published: 08/13/2009
• Est. Priority Date: 02/08/2008
• Status: Abandoned Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Morgan, Andre M., Tambs, Gary Edward, Subramanayam, Ravi, Barnes, Virginia Monsul, Chopra, Suman, Leite, Sergio, Sullivan, Richard J., Robinson, Richard Scott, Kohli, Rajnish, Wu, Donghui, Simon, Eric A., Santarpia, Ralph Peter III, Prencipe, Michael, Cummins, Diane, Wang, Qin, Mello, Sarita V., Zaidel, Lynette
• Application Number:
  US12/058,278
• Publication Number:
  US 20090202450A1
• Time in Patent Office: Days
• US Class Current: 424/50
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to oral care compositions comprising an effective amount of a basic amino acid in free or salt form, together with an anionic surfactant, and to methods of using and of making such compositions.

Claims

1. An oral care composition comprising

a. an effective amount of a basic amino acid, in free or salt form;

b. an anionic surfactant; and

c. an additional agent selected from an effective amount of an antibacterial agent;

an effective amount of a fluoride source;

an anionic polymer; and

combinations thereof.

2. A composition according claim 1 wherein the basic amino acid is arginine.

3. A composition according to claim 1 wherein the basic amino acid is in salt form and selected from arginine phosphate, arginine bicarbonate, and arginine hydrochloride.

4. A composition according to claim 1 wherein the anionic surfactant is selected from sodium lauryl sulfate and sodium laureth sulfate and mixtures thereof.

5. A composition according to claim 1 wherein the anionic surfactant is present in an amount of from about 0.01 to about 10 weight %.

6. A composition according to claim 1 wherein the anionic surfactant is present in an amount of from about 0.3 to about 4.5 weight %.

7. A composition according to claim 1 comprising a fluoride source selected from sodium fluoride and sodium monofluorophosphate.

8. A composition according to claim 1 further comprising an antibacterial agent.

9. A composition according to claim 8 wherein the antibacterial agent is triclosan.

10. A composition according to claim 1 further comprising an anionic polymer.

11. A composition according to claim 10 wherein the anionic polymer is a copolymer of methyl vinyl ether and maleic anhydride.

12. A composition according to claim 1 which is a dentifrice comprising

a. an effective amount of a salt of a basic amino acid selected from arginine bicarbonate, arginine phosphate and arginine hydrochloride;

b. an effective amount of triclosan;

c. an effective amount of a soluble fluoride salt selected from sodium fluoride and sodium monofluophosphate;

d. an anionic surfactant selected from sodium lauryl sulfate and sodium laureth sulfate.

13. A composition according to claim 1 further comprising xylitol.

14. A composition according to claim 1 comprising a particulate material selected from silica and calcium carbonate.

15. A composition according to claim 1 wherein the radioactive dentin abrasion (RDA) is less than about 150.

16. The composition claim 1 in the form of a toothpaste further comprising one or more of water, abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, humectants, thickeners, antimicrobial agents, preservatives, flavorings, colorings and/or combinations thereof.

17. A method comprising applying an effective amount of the oral composition of claim 1 to the oral cavity of a subject in need thereof to

a. reduce or inhibit formation of dental caries,

b. reduce, repair or inhibit early enamel lesions,

c. reduce or inhibit demineralization and promote remineralization of the teeth,

d. reduce hypersensitivity of the teeth,

e. reduce or inhibit gingivitis,

f. promote healing of sores or cuts in the mouth,

g. reduce levels of acid producing bacteria,

h. to increase relative levels of arginolytic bacteria,

i. inhibit bacterial attachment or microbial biofilm formation in the oral cavity,

j. raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge,

k. reduce plaque accumulation,

l. treat dry mouth,

m. whiten teeth,

n. enhance systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues,

o. reduce erosion of the teeth,

p. immunize the teeth against cariogenic bacteria, and/or

q. clean the teeth and oral cavity.

18. The method of claim 17 to inhibit bacterial attachment or microbial biofilm formation.

19. An oral care composition comprising a basic amino acid, in free or salt form, and an anionic surfactant for reducing the adhesion of bacteria to tooth surfaces in an oral cavity of a subject.

20. An oral care composition according to claim 19 wherein the basic amino acid is present in an amount of from 0.1 to 20 wt % of the total composition weight.

21. An oral care composition according to claim 19 wherein the basic amino acid is present in an amount of from 1 to 10 wt % of the total composition weight.

22. An oral care composition according to claim 19 wherein the basic amino acid comprises arginine.

23. An oral care composition according to claim 19 further comprising an antibacterial agent in an amount of from 0.01 to 5 wt % of the total composition weight.

24. An oral care composition according to claim 23 wherein the antibacterial agent is present in an amount of from 0.01 to 1 wt % of the total composition weight.

25. An oral care composition according to claim 19 wherein the antibacterial agent is triclosan.

26. An oral care composition according to claim 19 further comprising a soluble fluoride salt in an amount of from 0.01 to 2 wt % of the total composition weight.

27. An oral care composition according to claim 19 further comprising a source of fluoride ions in an amount to provide 50 to 25,000 ppm by weight of fluoride ions in the total composition weight.

28. An oral care composition according to claim 26 wherein the soluble fluoride salt is selected from sodium fluoride, sodium monofluorophosphate, and mixtures thereof.

29. An oral care composition according to claim 19 wherein the anionic surfactant is present in an amount of from 0.01 to 10 wt % of the total composition weight.

30. An oral care composition according to claim 29 wherein the anionic surfactant is present in an amount of from 0.3 to 4.5 wt % of the total composition weight.

31. An oral care composition according to claim 29 wherein the anionic surfactant is selected from sodium lauryl sulfate, sodium laureth sulfate, and mixtures thereof.

32. An oral care composition according to claim 19 further comprising an abrasive material, the abrasive material including a small particle fraction comprising at least about 5 wt % of the total composition weight, wherein the particles of the small particle fraction have a d50 of less than 5 μ

m.

33. An oral care composition according to claim 32 wherein the small particle fraction comprising at least about 20 wt % of the total composition weight.

34. An oral care composition according to claim 32 wherein the abrasive material is selected from calcium carbonate, silica, and mixtures thereof.

35. An oral care composition according to claim 32 wherein the abrasive material comprises from 15 to 70 wt % of the total composition weight.

36. Use of a basic amino acid, in free or salt form, in an oral care composition comprising an anionic surfactant for reducing the adhesion of bacteria to tooth surfaces in an oral cavity of a subject.

37. Use according to claim 36 wherein the basic amino acid is present in an amount of from 0.1 to 20 wt % of the total composition weight.

38. Use according to claim 37 wherein the basic amino acid comprises arginine.

39. Use according to claim 36 wherein the anionic surfactant is present in an amount of from 0.01 to 10 wt % of the total composition weight.

40. Use according to claim 39 wherein the anionic surfactant is selected from sodium lauryl sulfate, sodium laureth sulfate, and mixtures thereof.

41. Use of a basic amino acid, in free or salt form, for the manufacture of a medicament which includes an anionic surfactant, for use in reducing the adhesion of bacteria to tooth surfaces in an oral cavity of a subject.

42. A method of reducing the adhesion of bacteria to tooth surfaces in an oral cavity of a subject, the method comprising treating the oral cavity with an oral care composition comprising a basic amino acid, in free or salt form, and an anionic surfactant.