Drug Delivery System Comprising Microparticles and Gelation System
First Claim
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1. A dual phase polymeric agent-delivery composition comprising:
- (a) a continuous aqueous phase comprising a reverse thermal gelation system comprising a blend of a cellulose derivative and polyethylene glycol;
(b) a discontinuous particulate phase comprising microparticles; and
(c) an agent to be delivered contained in at least said discontinuous particulate phase.
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Abstract
Disclosed are drug delivery compositions comprising a continuous aqueous phase comprising a reverse thermal gelation system comprising a blend of a cellulose derivative and polyethylene glycol; a discontinuous particulate phase comprising microparticles; and an agent to be delivered contained in at least said discontinuous particulate phase. Also disclosed are sustained release compositions formed using the drug delivery compositions and methods of using those compositions.
45 Citations
27 Claims
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1. A dual phase polymeric agent-delivery composition comprising:
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(a) a continuous aqueous phase comprising a reverse thermal gelation system comprising a blend of a cellulose derivative and polyethylene glycol; (b) a discontinuous particulate phase comprising microparticles; and (c) an agent to be delivered contained in at least said discontinuous particulate phase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A dual-phase sustained release gelled dosage form comprising
(a) a continuous hydrogel phase comprising a blend of a cellulose derivative and polyethylene glycol; -
(b) a discontinuous particulate phase comprising microparticles; and (c) an agent to be delivered contained in at least said discontinuous particulate phase. - View Dependent Claims (27)
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Specification