NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES
First Claim
Patent Images
1. A compound of formula I:
- wherein;
R1 is (C1-C6)alkyl, hydroxy(C1-C6)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, or halo, wherein each aryl or heteroaryl is optionally substituted with one or more groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, halo, amino, nitro, cyano, trifluoro, trifluoromethyl, or hydroxy; and
R2 is hydrogen, heteroaryl, halo, or aryl that is optionally substituted with one or more groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, halo, amino, nitro, cyano, trifluoro, trifluoromethyl, or hydroxy;
or a salt thereof;
provided that when R1 is unsubstituted phenyl, R2 is not hydrogen.
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Abstract
The invention provides compounds of formula I:
wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds.
73 Citations
13 Claims
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1. A compound of formula I:
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wherein; R1 is (C1-C6)alkyl, hydroxy(C1-C6)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, or halo, wherein each aryl or heteroaryl is optionally substituted with one or more groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, halo, amino, nitro, cyano, trifluoro, trifluoromethyl, or hydroxy; and R2 is hydrogen, heteroaryl, halo, or aryl that is optionally substituted with one or more groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, halo, amino, nitro, cyano, trifluoro, trifluoromethyl, or hydroxy; or a salt thereof; provided that when R1 is unsubstituted phenyl, R2 is not hydrogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification