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SENSORS EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS

  • US 20090203980A1
  • Filed: 12/01/2008
  • Published: 08/13/2009
  • Est. Priority Date: 11/29/2007
  • Status: Abandoned Application
First Claim
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1. A detector system comprising:

  • a competitor comprising an analog of a ligand of interest covalently coupled to a macromolecule;

    an artificial receptor configured to bind a ligand of interest and the competitor, binding of the ligand of interest competing with binding of the competitor;

    the artificial receptor comprising a plurality of different building block molecules independently covalently coupled to a solid support in a region;

    the region being a contiguous portion of the surface of the solid support with the different building block molecules distributed randomly throughout the contiguous region;

    a semipermeable membrane that is permeable to the ligand of interest but that retains an effective amount of the competitor;

    the semipermeable membrane and the artificial receptor at least partially defining a chamber, the competitor and the artificial receptor being in the chamber; and

    a detector operatively coupled to the artificial receptor and configured to, in response to binding of the competitor or the ligand of interest to the artificial receptor, produce indicia of presence or concentration of the ligand of interest.

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