MEDICAL DEVICE SYSTEM AND RELATED METHODS FOR DIAGNOSING ABNORMAL MEDICAL CONDITIONS BASED ON IN-VIVO OPTICAL PROPERTIES OF TISSUE
First Claim
1. A medical diagnostic system, comprising:
- a probe with a proximal end portion and a distal end portion with a tissue interface region;
at least one light delivery member coupled to the tissue interface region;
at least one light capture member coupled to the tissue interface region; and
a pressure sensor coupled to the tissue interface region.
2 Assignments
0 Petitions
Accused Products
Abstract
A diagnostic system detects abnormal physical properties of tissue in a patient based upon optical properties of the tissue. A probe includes light delivery and capture fibers, and polarizers. Optical properties detected relate to polarized and unpolarized light into, and scattering from, the tissue. The optical properties detected are processed and analyzed to produce results indicative of the physical property(s) evaluated. System operation is controlled against pressure monitored via a pressure sensor coupled to the probe-tissue interface. The analysis corrects for patient physical characteristics as user inputs, such as menopausal or menstrual condition of women patients. Physical properties diagnosed include cervical dysplasia conditions in women patients, such as HSIL, cervical cancer, LSIL, or cervicitis. Analysis and diagnosis is based upon at least one of: ratios between scattered light signals captured from the tissue, slope of intensity over wavelength for scattered light signals captured, and hemoglobin-related parameters in the tissue.
77 Citations
25 Claims
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1. A medical diagnostic system, comprising:
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a probe with a proximal end portion and a distal end portion with a tissue interface region; at least one light delivery member coupled to the tissue interface region; at least one light capture member coupled to the tissue interface region; and a pressure sensor coupled to the tissue interface region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for diagnosing a property of a region of tissue in a patient, comprising:
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placing a tissue interface region of a probe in contact with the region of tissue; delivering at least a first light illumination signal from the tissue interface region into the region of tissue in contact with the tissue interface region; collecting at least a first captured light signal from the region of tissue at the tissue interface region in response to the first light illumination signal delivered into the region of tissue; processing at least one measured parameter of at least the first captured light signal and producing a result that is useful in diagnosing the property of the region of tissue; monitoring a pressure at the tissue interface region in contact with the region of tissue; comparing the monitored pressure against a pressure threshold criteria; and producing the result only based upon the monitored pressure meeting the pressure threshold criteria.
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25. A medical diagnostic system, comprising:
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an optical measurement system configured to measure at least one light scattering property or light absorption property of tissue; a data analysis algorithm; and a processor coupled to the data analysis algorithm; wherein the data analysis algorithm run by the processor is configured to analyze data related to the measured optical property or properties in a manner that provides output information that is useful in diagnosing a property of the tissue; and wherein the data analysis algorithm adjusts the analysis and output information based upon physical characteristics of the patient input by the user.
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Specification