METHOD FOR ADMINISTERING A THERAPEUTIC AGENT INTO TISSUE

• US 20090204062A1
• Filed: 04/24/2009
• Published: 08/13/2009
• Est. Priority Date: 10/06/2003
• Status: Abandoned Application

• Current Assignee: Ceramatec, Inc.
• Original Assignee: Ceramatec, Inc.
• Inventors: Muto, Mario, Murphy, Kieran P.
• Application Number:
  US12/429,736
• Publication Number:
  US 20090204062A1
• Time in Patent Office: Days
• US Class Current: 604/25
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 2005/3114 Filling or refilling
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 25/065 Guide needles
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids

Abstract

An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

Claims

1. A method of treating pain, comprising:

identifying a pain site and injecting medical ozone into the pain site.

2. The method of claim 1, wherein injecting medical ozone comprises utilizing an apparatus for the self-contained generation and administration of medical ozone.

3. The method of claim 2, wherein the apparatus comprises:

a chamber for holding said agent;

a catheter for connecting said chamber to an area for administration of said agent;

a power supply;

a therapeutic agent generator in communication with said chamber, said generator connected to said power supply; and

a switch in operable communication with said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent.

4. The method of claim 2, wherein said medical ozone comprises a ratio of ozone (O₃) to oxygen (O₂).

5. The method of claim 4, wherein said ratio of ozone to oxygen is about 1 μ

g/ml.

6. The method of claim 4, wherein said ratio of ozone to oxygen is about 10 μ

g/ml.

7. The method of claim 4, wherein said ratio of ozone to oxygen is about 20 μ

g/ml.

8. The method of claim 4, wherein said ratio of ozone to oxygen is about 30 μ

g/ml.

9. The method of claim 4, wherein said ratio of ozone to oxygen is about 40 μ

g/ml.

10. The method of claim 4, wherein said ratio of ozone to oxygen is about 50 μ

g/ml.

11. The method of claim 4, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μ

g/ml and about 90 μ

g/ml.

12. The method of claim 11, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 80 μ

g/ml.

13. The method of claim 12, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μ

g/ml and about 70 μ

g/ml.

14. The method of claim 13, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 34 μ

g/ml.

15. The method of claim 14, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μ

g/ml to about 28 μ

g/ml.

16. A method of treating pain, comprising:

activating an ozone generator external to the patient;

creating a specific concentration of O3/O2 gas mixture on the ozone generator;

aspirating the O3/O2 gas mixture into the syringe; and

injecting a predetermined volume of a fixed concentration of ozone/oxygen gas mixture into the pain site.

17. The method of claim 16, wherein injecting medical ozone comprises utilizing an apparatus for the self-contained generation and administration of medical ozone.

18. The method of claim 17, wherein the apparatus comprises:

a chamber for holding said agent;

a catheter for connecting said chamber to an area for administration of said agent;

a power supply;

a therapeutic agent generator in communication with said chamber, said generator connected to said power supply; and

a switch in operable communication with said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent.

19. The method of claim 17, wherein said medical ozone comprises a ratio of ozone (O₃) to oxygen (O₂).

20. The method of claim 19, wherein said ratio of ozone to oxygen is about 1 μ

g/ml.

21. The method of claim 19, wherein said ratio of ozone to oxygen is about 10 μ

g/ml.

22. The method of claim 19, wherein said ratio of ozone to oxygen is about 20 μ

g/ml.

23. The method of claim 19, wherein said ratio of ozone to oxygen is about 30 μ

g/ml.

24. The method of claim 19, wherein said ratio of ozone to oxygen is about 40 μ

g/ml.

25. The method of claim 19, wherein said ratio of ozone to oxygen is about 50 μ

g/ml.

26. The method of claim 19, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μ

g/ml and about 90 μ

g/ml.

27. The method of claim 26, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 80 μ

g/ml.

28. The method of claim 27, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μ

g/ml and about 70 μ

g/ml.

29. The method of claim 28, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 34 μ

g/ml.

30. The method of claim 29, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μ

g/ml to about 28 μ

g/ml.

31. The method of claim 16, further comprising capturing unused ozone in a scavenger.

32. A method of treating pain, comprising:

identifying the pain site with an imaging device;

inserting a needle at or near the pain site;

injecting nonionic x-ray dye through the needle into the area or the pain site;

performing a discogram of the pain site;

activating an ozone generator external to the patient;

selecting a specific concentration of O3/O2 gas mixture on the ozone generator;

attaching a scavenger and a syringe to the ozone generator;

aspirating the O3/O2 gas mixture into the syringe;

injecting a predetermined volume of a fixed concentration of ozone/oxygen gas mixture into the pain site;

capturing unused ozone in the charcoal scavenger; and

,

removing all needles.

33. The method of claim 32, wherein injecting medical ozone comprises utilizing an apparatus for the self-contained generation and administration of medical ozone.

34. The method of claim 33, wherein the apparatus comprises:

a chamber for holding said agent;

a catheter for connecting said chamber to an area for administration of said agent;

a power supply;

a therapeutic agent generator in communication with said chamber, said generator connected to said power supply; and

a switch in operable communication with said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent.

35. The method of claim 33, wherein said medical ozone comprises a ratio of ozone (O₃) to oxygen (O₂).

36. The method of claim 35, wherein said ratio of ozone to oxygen is about 1 μ

g/ml.

37. The method of claim 35, wherein said ratio of ozone to oxygen is about 10 μ

g/ml.

38. The method of claim 35, wherein said ratio of ozone to oxygen is about 20 μ

g/ml.

39. The method of claim 35, wherein said ratio of ozone to oxygen is about 30 μ

g/ml.

40. The method of claim 35, wherein said ratio of ozone to oxygen is about 40 μ

g/ml.

41. The method of claim 35, wherein said ratio of ozone to oxygen is about 50 μ

g/ml.

42. The method of claim 35, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μ

g/ml and about 90 μ

g/ml.

43. The method of claim 42, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 80 μ

g/ml.

44. The method of claim 43, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μ

g/ml and about 70 μ

g/ml.

45. The method of claim 44, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 34 μ

g/ml.

46. The method of claim 45, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μ

g/ml to about 28 μ

g/ml.