One-Hand Operated Drug Mixing and Expelling Device

• US 20090204066A1
• Filed: 06/07/2007
• Published: 08/13/2009
• Est. Priority Date: 06/21/2006
• Status: Active Grant

• Current Assignee: Novo Nordisk Health Care AG (Novo Nordisk A/S)
• Original Assignee: Novo Nordisk A/S
• Inventors: Radmer, Bo, Revsgaard Fredriksen, Morten
• Granted Patent: US 8,323,237 B2
• Time in Patent Office: Days
• US Class Current: 604/86
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2037 having valve means
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

A drug mixing and expelling device (1) for mixing a drug with a liquid, thereby forming a reconstituted liquid drug. The device comprises a reservoir (2) containing a liquid, a vial (4) containing a drug, a vial, means (5) for establishing a fluid connection between the reservoir and a vial positioned in the vial adapter (3), means (7, 8) for forcing the liquid from the reservoir to a vial, and means (9) for activating said forcing means during establishment of the fluid connection between the reservoir and the vial. The forcing of liquid into the vial provides a pressure therein, which can be used for infusion of the reconstituted drug directly from the vial. The device also comprises a suction unit (13) for aspiration.

Claims

1. A drug mixing and expelling device comprising:

a reservoir containing a liquid,

a vial containing a drug,

means for establishing a fluid connection between the reservoir and the vial and for establishing fluid connection between the vial and an infusion outlet,

integrated forcing means with accumulated or latent energy stored for forcing the liquid from the reservoir to the vial via an established fluid connection, and

activating means for activating said integrated forcing means upon establishment of said fluid connection between the reservoir and the vial.

2. A drug mixing and expelling device according to claim 1, wherein the reservoir for liquid, the vial, the means for establishing said fluid connections, the forcing means and the means for activating form an integral device.

3. A drug mixing and expelling device according to claim 1, wherein the means for establishing a fluid connection comprises a first spike adapted to penetrate a septum of the vial.

4. A drug mixing and expelling device according to claim 3, wherein the means for establishing a fluid connection further comprises a second spike adapted to penetrate a septum of the reservoir.

5. A drug mixing and expelling device according to claim 1, wherein said activating means is adapted to activate the forcing means during pressing the vial towards the first spike for penetrating the septum.

6. A drug mixing and expelling device according to claim 1, wherein the means for establishing a fluid connection comprises a valve system for opening and closing a fluid connection between the vial and reservoir.

7. A drug mixing and expelling device according to claim 1, wherein the forcing means comprises a piston or plunger provided in the reservoir and adapted to force the liquid into the vial.

8. A drug mixing and expelling device according to claim 7, wherein the piston or plunger is at least one of spring driven, pneumatic driven, electrically driven, gas driven or expanding material driven, the force acting on the piston or plunger being adapted to keep the piston or plunger in an end position in which the liquid has been forced into the vial.

9. A drug mixing and expelling device according to claim 7, wherein the force acting on the piston or plunger is adapted to move the liquid reservoir towards the vial for establishing the fluid connection.

10. A drug mixing and expelling device according to claim 1, wherein a valve is provided for opening and closing the fluid connection between the vial and the infusion outlet for controlling the flow rate.

11. A drug mixing and expelling device according to claim 10, wherein the valve is a variable flow controlled valve.

12. A drug mixing and expelling device according to claim 1, wherein a suction unit is provided at a location between said vial and the infusion outlet for aspirating.

13. A drug mixing and expelling device according to claim 12, wherein the suction unit comprises a syringe with a syringe plunger rod.

14. A drug mixing and expelling device according to claim 13, wherein the syringe is a one-way syringe only allowing its piston to move in the suction direction.

15. A drug mixing and expelling device according to claim 12, wherein the suction unit comprises syringe having an air permeable membrane.

16. A drug mixing and expelling device according to claim 10, and comprising a suction unit that comprises a pump with an inlet and outlet tube connected on opposite sides of said valve, respectively, said inlet and outlet tubes each comprising a one-way valve.

17. A drug mixing and expelling device according to claim 16, wherein the pump is manually or electrically driven or driven by the force provided by the spring acting on the piston.

18. A drug mixing and expelling device according to claim 12, wherein the suction unit is connected to a chamber provided on an opposite side of the piston or plunger in relation to the liquid in the reservoir, so that a suction process is provided through the suction unit, when said piston forces the liquid into the vial.

19. A drug mixing and expelling device according to claim 12, wherein the reservoir for liquid, the vial, the means for establishing said fluid connections, the forcing means and the means for activating the suction unit form an integral device.