Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel
First Claim
1. A method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe, comprising:
- forming a therapeutic agent into a plurality of microparticles;
dispersing the microparticles throughout a pharmaceutically acceptable liquid carrier to form a therapeutic mixture;
providing a catheter, the catheter including a microsyringe operably attached to an actuator, the microsyringe including a hollow needle in fluid communication with a therapeutic agent delivery conduit, wherein the actuator is operable between an unactuated condition in which the needle is enclosed within the actuator and an actuated condition in which the needle is thrust outward by the actuator;
introducing the catheter into a target area of a vessel;
operating the actuator such that the needle is thrust outward and into a wall of the vessel;
supplying the therapeutic mixture to the therapeutic agent delivery conduit;
delivering the therapeutic mixture through the therapeutic agent delivery conduit to the needle and through the needle into an adventitia of the vessel;
operating the actuator such that the needle is withdrawn from the wall of the vessel and enclosed within the actuator; and
removing the catheter from the vessel.
1 Assignment
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Accused Products
Abstract
The invention provides a method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe. A therapeutic agent is formed into microparticles, which are dispersed throughout an appropriate liquid carrier to form a therapeutic mixture. A catheter is provided that includes a microsyringe operably attached to an actuator. The microsyringe includes a hollow needle in fluid communication with a therapeutic agent delivery conduit. The catheter is introduced into a target area of a vessel. The actuator is operated to thrust the needle into a wall of the vessel. The therapeutic mixture is supplied to the therapeutic agent delivery conduit and delivered through the conduit to the needle and thereby into the adventitia of the vessel. The actuator is again operated to withdraw the needle from the wall of the vessel and to enclose it within the actuator. The catheter is then removed from the vessel.
23 Citations
28 Claims
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1. A method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe, comprising:
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forming a therapeutic agent into a plurality of microparticles; dispersing the microparticles throughout a pharmaceutically acceptable liquid carrier to form a therapeutic mixture; providing a catheter, the catheter including a microsyringe operably attached to an actuator, the microsyringe including a hollow needle in fluid communication with a therapeutic agent delivery conduit, wherein the actuator is operable between an unactuated condition in which the needle is enclosed within the actuator and an actuated condition in which the needle is thrust outward by the actuator; introducing the catheter into a target area of a vessel; operating the actuator such that the needle is thrust outward and into a wall of the vessel; supplying the therapeutic mixture to the therapeutic agent delivery conduit; delivering the therapeutic mixture through the therapeutic agent delivery conduit to the needle and through the needle into an adventitia of the vessel; operating the actuator such that the needle is withdrawn from the wall of the vessel and enclosed within the actuator; and removing the catheter from the vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of compounding a therapeutic agent for delivery to the adventitia of a vessel using a catheter-based microsyringe, comprising:
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forming a therapeutic agent into a plurality of microparticles; and dispersing the microparticles throughout a liquid carrier suitable for delivery to an adventitia of a vessel. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification