EXTRACELLULAR MATRIX COMPOSITE MATERIALS, AND MANUFACTURE AND USE THEREOF
First Claim
1. A medical graft material, comprising an acellular extracellular matrix composite including a first extracellular matrix material having a surface, and a second, biosynthetically-deposited extracellular matrix material on said surface.
2 Assignments
0 Petitions
Accused Products
Abstract
Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material.
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Citations
44 Claims
- 1. A medical graft material, comprising an acellular extracellular matrix composite including a first extracellular matrix material having a surface, and a second, biosynthetically-deposited extracellular matrix material on said surface.
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17-30. -30. (canceled)
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31. An extracellular matrix graft prosthesis conditioned with matrix components, comprising:
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a bioremodelable extracellular matrix graft material essentially free of cells and cell components; and biosynthetically-deposited exogenous extracellular matrix components on said bioremodelable extracellular matrix graft material. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44-49. -49. (canceled)
Specification