METHOD AND INSTALLATION FOR REGULATING THE MODIFIER LEVEL IN CHROMATOGRAPHY OR SUPERCRITICAL EXTRACTION WITH RECYCLING
First Claim
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1. A chromatography or extraction method, including:
- a separating operation (1) in a column or an extractor, with the said column or the said extractor receiving a product (P) and feeding into an eluent that includes a supercritical fluid, routed via a first pumping operation (2), and a modifier, routed via at least one second pumping operation (3),an operation (4) for collecting at least one fraction of the product (P) downstream of the column or extractor,an operation (5) for recycling the supercritical fluid mixed with a residual quantity of modifier, following after the collecting operation (4) and preceding the first pumping operation (2), with the said first pumping operation being used to pump at least the said supercritical fluid mixed with a residual quantity of modifier, anda condensing operation (6) following after the collecting operation (4) and preceding the first pumping operation (2),the said method being characterised in that it further includes;
downstream of the collecting operation (4) and upstream of the separating operation (1), an operation for determining at least one magnitude associated with the level of modifier mixed with the recycled supercritical fluid, and if necessaryan operation (8) for correcting the flow in the first pumping operation (2) and the flow in the second pumping operation (3), in order to limit the variations, during execution of the method, of the modifier level in the eluent at the input to the column or of the extractor, in a direction that is suitable for meeting a first setpoint, determined beforehand, for the total flow corresponding to the sum of the flows in the first-pumping operation (2) and in the second pumping operation (3).
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Abstract
A chromatography or supercritical extraction method is disclosed, in which the eluent comprises a mixture of a fluid and a modifier and in which the fluid is recycled. One exemplary method comprises an operation consisting in determining at least one quantity linked to the level of modifier that is mixed with the recycled fluid and, if necessary, a correction operation in order to limit variations in the level of modifier in the eluent at the inlet of the column or the extractor. The disclosure also relates to a chromatography or extraction installation.
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Citations
18 Claims
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1. A chromatography or extraction method, including:
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a separating operation (1) in a column or an extractor, with the said column or the said extractor receiving a product (P) and feeding into an eluent that includes a supercritical fluid, routed via a first pumping operation (2), and a modifier, routed via at least one second pumping operation (3), an operation (4) for collecting at least one fraction of the product (P) downstream of the column or extractor, an operation (5) for recycling the supercritical fluid mixed with a residual quantity of modifier, following after the collecting operation (4) and preceding the first pumping operation (2), with the said first pumping operation being used to pump at least the said supercritical fluid mixed with a residual quantity of modifier, and a condensing operation (6) following after the collecting operation (4) and preceding the first pumping operation (2), the said method being characterised in that it further includes; downstream of the collecting operation (4) and upstream of the separating operation (1), an operation for determining at least one magnitude associated with the level of modifier mixed with the recycled supercritical fluid, and if necessary an operation (8) for correcting the flow in the first pumping operation (2) and the flow in the second pumping operation (3), in order to limit the variations, during execution of the method, of the modifier level in the eluent at the input to the column or of the extractor, in a direction that is suitable for meeting a first setpoint, determined beforehand, for the total flow corresponding to the sum of the flows in the first-pumping operation (2) and in the second pumping operation (3). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A chromatography or extraction installation including:
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a separating device such as one or more chromatography columns (12) or an extractor, which receives a product (P) and feeds into an eluent that includes a supercritical fluid, routed via a first pump (13), and a modifier, routed via at least one second pump (14), a device (15) for collecting at least one fraction of the product (P) separated in the separating device, a path (16) for recycling the supercritical fluid mixed with a residual quantity of modifier, downstream of the collecting device (15) and upstream of the first pump (13), with the said first pump pumping at least the said supercritical fluid mixed with a residual quantity of modifier, and a condenser (17) placed downstream of the collecting device (15) and upstream of the first pump (13), the said installation being characterised in that it further includes a measuring and correcting device (18), placed in the recycling path (16) or in, downstream of the first pump (13) and upstream of the separating device, which measures at least one magnitude associated with the level of modifier mixed with the recycled supercritical fluid and that, if necessary, performs correction of the flow in the first pump (13) and of the flow in the second pump (14), in order to limit the variations, while running the installation, of the said levels at the input to the separating device, in a direction that is suitable for meeting a first setpoint, determined beforehand, for the total flow corresponding to the sum of the flows in the first pump (13) and in the second pump (14). - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification