SYSTEM AND METHOD FOR QUANTITATIVE IMAGING OF CHEMICAL COMPOSITION TO DECOMPOSE MULTIPLE MATERIALS

• US 20090207967A1
• Filed: 02/13/2009
• Published: 08/20/2009
• Est. Priority Date: 02/15/2008
• Status: Active Grant

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: McCollough, Cynthia H., Liu, Xin, Yu, Lifeng
• Granted Patent: US 7,885,373 B2
• Time in Patent Office: Days
• US Class Current: 378/5
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4014 arranged in multiple source-detector units
• CPC Class Codes: A61B 6/4241 using energy resolving detectors, e.g. photon counting
• CPC Class Codes: A61B 6/482 involving multiple energy imaging

Abstract

The present invention provides a material decomposition method capable of determining the distribution of density and constituent material concentration throughout an imaged object. The concentration, in the form of a mass fraction, mass percent, weight fraction, or weight percent, is determined from CT images acquired at different energy levels. The ratio of attenuation coefficients associated with one energy level to attenuation coefficients associated with another energy level is determined and used as an index in a lookup table to determine the concentration of a given material throughout the imaged object.

Claims

1. A method for determining a material decomposition using a CT system, the steps comprising:

a) imaging an object with the CT system using at least two different energy levels to acquire CT data associated with each of the energy levels;

b) reconstructing the acquired CT data associated with each of the energy levels to produce image data associated with each of the energy levels;

c) converting the image data associated with each of the energy levels to attenuation coefficients associated with each of the energy levels;

d) calculating a ratio of the attenuation coefficients associated with one energy level to the attenuation coefficients associated with another energy level; and

e) correlating the ratio calculated in step d) to indicate a concentration of a constituent material in the imaged object.

2. The method as recited in claim 1 further including step f) correlating the concentration of a constituent material to the image data to create an image showing a distribution of the concentrations of the constituent material.

3. The method as recited in claim 1 wherein the CT system is at least one of a dual-energy, single-source CT system;

a dual-source, dual-energy CT system;

a photon counting CT system; and

an energy discriminating CT system.

4. The method as recited in claim 1 wherein step e) further includes comparing the ratio calculated in step d) to a lookup table relating attenuation coefficient ratios to the concentration of the constituent material.

5. The method as recited in claim 4 wherein the concentration is at least one of a mass fraction, mass percent, weight fraction, and weight percent.

6. The method as recited in claim 1 wherein step e) includes calculating an effective density.

7. The method as recited in claim 6 wherein concentration is determined for two constituent materials in the imaged object.

8. The method as recited in claim 7 wherein step c) further includes expressing the attenuation coefficients associated with each energy level as a weighted sum of the attenuation coefficients of the constituent materials.

9. A method for determining a material decomposition using a CT system, the steps comprising:

a) imaging an object with the CT system using at least two different energy levels to acquire CT data associated with each of the energy levels;

b) reconstructing the acquired CT data associated with each of the energy levels to produce image data associated with each of the energy levels;

c) converting the image data associated with each of the energy levels to attenuation coefficients associated with each of the energy levels;

d) selecting corresponding portions of the image data associated with each of the energy levels;

e) calculating a ratio of the attenuation coefficients associated with the selected corresponding portions of the image data;

f) determining from the ratio calculated in step e) a concentration of a constituent material in the portion of the imaged object corresponding to selected corresponding portions of the image data;

g) repeating steps d) through f) to determine a concentration of a constituent material in the imaged object; and

h) creating a representation of the object indicating the constituent material in the imaged object.

10. The method as recited in claim 9 wherein the CT system is at least one of a dual-energy, single-source CT system and a dual-source, dual-energy CT system.

11. The method as recited in claim 9 wherein step f) further includes comparing the ratio calculated in step e) to a lookup table relating attenuation coefficient ratios to the concentration of the constituent material.

12. The method as recited in claim 11 wherein the concentration is at least one of a mass fraction, mass percent, weight fraction, and weight percent.

13. The method as recited in claim 9 wherein step f) includes calculating an effective density.

14. The method as recited in claim 13 wherein concentration is determined for two constituent materials in the selected corresponding portions of the image data.

15. The method as recited in claim 14 wherein step c) further includes expressing the attenuation coefficients associated with each energy level as a weighted sum of the attenuation coefficients of the constituent materials.