CONTROLLABLE MAGNETIC SYSTEM FOR BIOSENSORS

• US 20090209042A1
• Filed: 05/08/2007
• Published: 08/20/2009
• Est. Priority Date: 05/10/2006
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Prins, Menno Willem Jose, Immink, Albert Hendrik Jan, Van Lankvelt, Petrus Johannus Wilhelmus
• Application Number:
  US12/299,788
• Publication Number:
  US 20090209042A1
• Time in Patent Office: Days
• US Class Current: 436/149
• CPC Class Codes: G01N 27/745 for detecting magnetic beads used in biochemical assays concerning the assays G01N33/54326; sensors therefor G01R33/1269; automatic analysers therefor G01N35/0098
• CPC Class Codes: G01N 33/54333 Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Abstract

The invention relates to a magnetic system for biosensors and in particular to a magnetic system which can switch between attraction force and repulsion force near the sensor surface with more easy but also more effective means. This is realised with at least one coil (2) and at least two ferromagnetic cores (3) which are arranged in a concentric multilayered package, and a sensor or a sensor surface exposed to or covered with the biomaterial, which is arranged near to the magnetic system.

Claims

1. A magnetic system for biosensors, with at least one coil (2) and at least two ferromagnetic cores (3) which are arranged in a concentric multilayered package, and a sensor or a sensor surface exposed to or covered with the biomaterial, which is arranged near to the magnetic system.

2. A magnetic system, according to claim 1, characterized in that the coil (2) comprises two concentric coil layers and the core (3) comprises two concentric core material layers which are arranged in a multilayered package.

3. A magnetic system, according to claim 1, characterized in that one concentric coil layer and two concentric core material layers are arranged in a multilayered package, wherein the two core material layers are connected together at the bottom of the magnet system.

4. A magnetic system, according to claim 2, characterized in that the coils (2) are electrically controllable independently from each other.

5. A magnetic system according to claim 1, characterized in that two coils (2) and two magnetic cores (3) are arranged in such a way, that an inner magnetic system consisting of a coil (2) and a magnetic core (3) influenced by this inner coil is surrounded by an outer coil and an outer magnetic core is influenced by this outer coil (2).

6. A magnetic system according to claim 1, characterized in that the biomaterial is filled in a cartridge which is positioned in the influence area of the magnetic field.

7. A magnetic system according to claim 1, characterized in that an opening in the magnetic system is arranged at that side, where the sensor is located, which is created by a shift of the inner core (3) or the inner core-coil arrangement.

8. A magnetic system for biosensors according to claim 7, characterized in that the opening in the magnetic core (3) is a cylindrical blind hole.

9. A magnetic system for biosensors according to claim 7, characterized in that the opening in the core (3) is a cone shaped hole or opening.

10. A magnetic system for biosensors according to claim 7, characterized in that the opening in the core (3) has a rectangular or a squared cross section.

11. A magnetic system for biosensors according to claim 1, characterized in that adjacent to the magnet a second magnet is arranged, separated over a gap.

12. A magnetic system for biosensors according to claim 1, characterized in that the sensor is an array of several sensors.

13. Method for operating a magnetic system with biosensor as described in claim 1, by which a sensing material or liquid is dispersed with or chemically bound to microscopic magnetic beads, and the sensor chip is positioned in a such a position, that by generating magnetic repulsion near the sensor surfaces area is caused a washing of the surface by repulsion forces of the magnetic beads, and that by generating magnetic attraction forces near the sensor surfaces area is caused attraction forces to the magnetic beads for sensing the biosubstrate in a very close contact to the sensor surface.

14. Method according to claim 13, characterized in that the inner coil (2) or coil layer is applied with a current, or with a dominating current in comparison with the current in the outer coil (2), in order to produce a repulsive magnetic force.

15. Method according to claim 13, characterized in that the outer coil (2) or coil layer is applied with a current, or with a dominating current in comparison with the current in the inner coil (2), in order to produce an attractive magnetic force.

16. Method according to claim 14, characterized in that a soft switch between repulsive magnetic force and attractive magnetic force is generated by a balance control of the currents amperage and/or currents polarity.