Method and Device for Determining Flow in a Blood Vessel

• US 20090209872A1
• Filed: 09/12/2006
• Published: 08/20/2009
• Est. Priority Date: 09/15/2005
• Status: Abandoned Application

• Current Assignee: Martil Instruments BV
• Original Assignee: Martil Instruments BV
• Inventors: Pop, Gheorghe Aurel Marie
• Application Number:
  US11/991,982
• Publication Number:
  US 20090209872A1
• Time in Patent Office: Days
• US Class Current: 600/506
• CPC Class Codes: A61B 5/027 using catheters
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295

Abstract

The invention relates to a method and device for determining the flow in a blood vessel, comprising the determining the relation between the shear rate and the impedance of flowing blood, measuring the impedance in the blood in a cross-section of the blood vessel, determining the shear rate from this relation and the measured impedance, determining the size of the cross-section of the blood vessel, selecting a theoretical relative flow distribution over the blood vessel cross-section, determining the average flow speed on the basis of the average shear rate and the relative flow distribution, and determining the flow volume from the determined average flow speed and the cross-section.

Claims

1. Method for determining the flow in a blood vessel, comprising of

a) determining the relation between the average shear rate and the electrical impedance of flowing blood,

b) measuring the electrical impedance in the blood in a cross-section of the blood vessel,

c) determining the average shear rate from this relation and the measured electrical impedance,

d) determining the size of the cross-section of the blood vessel,

e) selecting a theoretical relative flow distribution over the blood vessel cross-section,

f) determining the average flow speed on the basis of the shear rate and the relative flow distribution, and

g) determining the flow volume from the determined average flow speed and the cross-section.

2. Method as claimed in claim 1, wherein the steps a, c, e, and f are approximated by determining the relation between the average flow speed and the electrical impedance of flowing blood, and determining the average flow speed from this relation and the measured electrical impedance.

3. Method as claimed in claim 1, wherein the blood vessel is the right atrium of a heart and the determined flow volume is that of the heart.

4. Method as claimed in claim 3, wherein the electrical impedance measurement is performed with a catheter introduced into the right atrium.

5. Method as claimed in claim 1, wherein the electrical impedance measurement is performed in a determined period of the ECG.

6. Method as claimed in claim 5, wherein the electrical impedance measurement is performed during a number of heart cycles, in each case in the determined period of the ECG, and the average of the number of measurements is used to determine the electrical impedance.

7. Method as claimed in claim 6, wherein the determined period is the diastole.

8. Method as claimed in claim 1, wherein determination of the relation between the average shear rate and the electrical impedance in flowing blood further comprises of determining in vitro factors co-determining the electrical impedance of blood, such as the hematocrit and fibrinogen content.

9. Method as claimed in claim 1, wherein determination of the relation between the shear rate and the electrical impedance in flowing blood further comprises of determining in vitro the average shear rate at which the electrical impedance measured in the blood vessel occurs.

10. Method as claimed in claim 1, wherein determination of the relation between the average flow speed and the electrical impedance in flowing blood further comprises of determining in vitro the average flow speed at which the electrical impedance measured in the blood vessel occurs.

11. Method as claimed in claim 1, wherein steps a, c, f and g are performed by generating a blood flow with the chosen relative flow distribution in a vessel of a determined cross-section, measuring the electrical impedance centrally in this vessel in relation to the flow volume of the blood flow and, from the flow volume corresponding with the electrical impedance measured in the blood vessel in accordance with this relation, determining the flow volume in the blood vessel in accordance with the respective sizes of the cross-sections of the blood vessel and the vessel.

12. Method as claimed in claim 1, wherein the size of the blood vessel cross-section is determined with echography.

13. Method as claimed in claim 1, wherein as theoretical relative flow distribution over the blood vessel cross-section a relative flow distribution is chosen which a Newtonian liquid flowing in laminar manner would display over such a cross-section.

14. Device for determining the flow in a blood vessel, comprising

means for measuring the electrical impedance in the blood in a cross-section of a blood vessel,

means for determining the size of the blood vessel cross-section, and

processing means, comprising

memory means having stored therein a determined relation between the shear rate and the electrical impedance of flowing blood and for storing a theoretical relative flow distribution over the blood vessel cross-section, and computing means for determining the shear rate from the stored relation and the measured electrical impedance, for determining the average flow speed on the basis of the shear rate and the stored relative flow distribution, and for determining the flow volume from the determined average flow speed and the cross-section.

15. Device as claimed in claim 14, wherein a determined relation between the average flow speed and the electrical impedance of flowing blood is stored in the memory means, and the computing means can determine the average flow speed from the stored relation and the measured electrical impedance and the flow volume from the determined average flow speed and the cross-section.

16. Device as claimed in claim 14, further comprising a viscosity measuring apparatus comprising a conduit forming a blood vessel flow, moving means incorporated in the conduit for allowing a liquid to flow through the conduit at an adjustable flow speed, electrodes positioned in the conduit and electrical impedance measuring means connected to the electrodes.