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Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof

  • US 20090214505A1
  • Filed: 04/16/2009
  • Published: 08/27/2009
  • Est. Priority Date: 03/05/2003
  • Status: Active Grant
First Claim
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1. A method for treating a subject having an excess of a substrate for a hyaluronidase, comprising:

  • administering an amount of a soluble hyaluronidase glycoprotein (sHASEGP) sufficient to reduce that amount of the substrate to effect treatment, wherein;

    the sHASEGP is a soluble neutral active glycoprotein that contains at least one sugar moiety that is covalently attached to an asparagine residue; and

    the sHASEGP contains a sequence of amino acids included in SEQ ID NO;

    1 or a sequence that has at least about 91% amino acid sequence identity with a sequence of amino acids included in SEQ ID NO;

    1, whereby the sHASEGP is soluble, N-glycosylated and neutral active.

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