Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
First Claim
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1. A nitric oxide-releasing particle, the nitric oxide-releasing particle comprising:
- (a) a nitric oxide donor;
(b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of;
(i) a metallic cluster;
(ii) a dendritic network;
(iii) a co-condensed silica network; and
(iv) a combination thereof; and
(c) an exterior region.
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Abstract
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
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Citations
69 Claims
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1. A nitric oxide-releasing particle, the nitric oxide-releasing particle comprising:
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(a) a nitric oxide donor; (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (i) a metallic cluster; (ii) a dendritic network; (iii) a co-condensed silica network; and (iv) a combination thereof; and (c) an exterior region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method of delivering nitric oxide to a subject, the method comprising:
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(a) providing a nitric oxide-releasing particle comprising; (i) a nitric oxide donor; (ii) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (1) a metallic cluster; (2) a dendritic network; (3) a co-condensed silica network; and (4) a combination thereof; and (iii) an exterior region; and (b) administering an effective amount of the nitric oxide-releasing particle to the subject. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. A method of treating a disease state in a subject in need of treatment thereof, the method comprising:
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(a) providing a nitric oxide-releasing particle comprising; (i) a nitric oxide donor; (ii) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (1) a metallic cluster; (2) a dendritic network; (3) a co-condensed silica network; and (4) a combination thereof; and (iii) an exterior region; and (b) administering an effective amount of the nitric oxide-releasing particle to the subject. - View Dependent Claims (60, 61)
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62. A pharmaceutical formulation comprising:
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(a) a nitric oxide-releasing particle comprising; (i) a nitric oxide donor; (ii) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (1) a metallic cluster; (2) a dendritic network; (3) a co-condensed silica network; and (4) a combination thereof; and (iii) an exterior region; and (b) a pharmaceutically acceptable carrier. - View Dependent Claims (63)
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64. A nitric oxide-releasing polymeric film comprising an organic polymer and a nitric oxide-releasing particle, said nitric oxide-releasing particle comprising:
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(a) a nitric oxide donor; (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (i) a metallic cluster; (ii) a dendritic network; (iii) a co-condensed silica network; and (iv) a combination thereof; and (c) an exterior region. - View Dependent Claims (65)
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66. A medical device comprising a nitric oxide-releasing polymeric film, wherein the nitric oxide-releasing film comprises an organic polymer and a nitric oxide-releasing particle, the nitric-oxide releasing particle comprising:
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(a) a nitric oxide donor; (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (i) a metallic cluster; (ii) a dendritic network; (iii) a co-condensed silica network; and (iv) a combination thereof; and (c) an exterior region. - View Dependent Claims (67, 68)
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69. A detergent comprising a nitric oxide-releasing particle, said nitric oxide-releasing particle comprising:
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(a) a nitric oxide donor; (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of; (i) a metallic cluster; (ii) a dendritic network; (iii) a co-condensed silica network; and (iv) a combination thereof; and (c) an exterior region.
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Specification