IMPLANT FOR INTRAOCULAR DRUG DELIVERY
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Accused Products
Abstract
An implant for intraocular drug delivery for the treatment of inflammatory or degenerative diseases. In one embodiment, the implant includes a body portion having a first end portion and a second, opposite end portion and defining a cavity with a first opening at the first end portion, and a second, opposite opening at the second end portion, and a solid material received in the cavity, wherein the solid material comprises a depot material and an effective amount of at least one therapeutic compound or agent. When the implant is implanted in an eye of a living subject, the effective amount of at least one therapeutic compound or agent is released to the environment of the implant through at least one of the first opening and the second, opposite opening over an extended period of time.
107 Citations
74 Claims
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1-61. -61. (canceled)
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62. A method of treating an inflammatory or degenerative disease in or around the eye, comprising the steps of:
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a. providing to the eye an eye implant, the eye implant comprising; i. an effective amount of at least one therapeutic agent, the at least one therapeutic agent comprising at least one anti-TNFα
antibody, nanobody, antibody fragment, or combination thereof;
anti-interleukine-1 antibody, nanobody, antibody fragment, or combination thereof;
anti-interleukine-6 antibody, nanobody, antibody fragment, or combination thereof;
anti-interleukine-12 antibody, nanobody, antibody fragment, or combination thereof;
or a combination thereof; andii. a coating or encapsulating material that coats or encapsulates the at least one therapeutic agent and stabilizes the at least one therapeutic agent; b. implanting the eye implant in an eye of a living subject, wherein the effective amount of at least one therapeutic agent is releasable to the environment of the eye implant over an extended period of time. - View Dependent Claims (63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74)
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Specification