METHODS AND COMPOSITIONS FOR TREATMENT OF SKIN

• US 20090214628A1
• Filed: 08/04/2006
• Published: 08/27/2009
• Est. Priority Date: 09/27/2004
• Status: Active Grant

• Current Assignee: Special Water Patents B.V.
• Original Assignee: Special Water Patents B.V.
• Inventors: de Rijk, Jan
• Granted Patent: US 9,499,419 B2
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 59/02 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A01N 59/04 Carbon disulfide; Carbon monoxide; Carbon dioxide
• CPC Class Codes: A01N 59/06 Aluminium; Calcium; Magnesium; Compounds thereof
• CPC Class Codes: A01N 59/08 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61Q 1/00 Make-up preparations; Body powders; Preparations for removing make-up
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: C02F 1/001 Processes for the treatment of water whereby the filtration technique is of importance C02F1/44 takes precedence; construction of filters in general B01D24/00 - B01D41/00
• CPC Class Codes: C02F 1/02 by heating methods of steam generation F22B; preheating boiler feed-water or accumulating preheated boiler feed-water F22D
• CPC Class Codes: C02F 1/32 with ultraviolet light
• CPC Class Codes: C02F 1/50 by addition or application of a germicide or by oligodynamic treatment C02F1/4606, C02F1/467, C02F1/76 take precedence
• CPC Class Codes: C02F 1/72 by oxidation C02F1/4672 takes precedence
• CPC Class Codes: C02F 1/78 : with ozone C02F1/4672 takes precedence
• CPC Class Codes: C02F 2103/42 : from bathing facilities, e.g. swimming pools
• CPC Class Codes: C02F 9/00 : Multistage treatment of water, waste water or sewage

Abstract

The present invention relates to compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or determatologic skin conditions. The invention relates to compositions for treating and ameliorating skin conditions including acne, rosacea and wrinkling caused by photodamage or conditions related to aging, hormonal imbalances, hyper-pigmentation, melasma, keratosis or the like. The invention can also be used to treat conditions of the scalp such as dandruff. The present invention also relates to compositions that can be used to remove biofilms from contact lenses. More particularly, this invention relates to a composition comprising (a) one or more metasilicate; (b) one or more carbonate; (c) one or more glyconate; and (d) one or more sulfate. The composition may also contain (e) salts, e.g., sea salts and other additives or active agents.

Claims

1. A composition for treating skin or scalp, comprising:

(a) one or more metasilicate;

(b) one or more carbonate;

(c) one or more glyconate; and

(d) one or more sulfate.

2. The composition of claim 1, wherein the one or more metasilicate is an alkali metal silicate selected from the group consisting of sodium or potassium metasilicate, sodium or potassium orthosilicate and mixtures thereof.

3. The composition of claim 1, wherein the one or more carbonate is selected from the group consisting of sodium carbonate, sodium sesquicarbonate, sodium sulfate, sodium bicarbonate and mixtures thereof.

4. The composition of claim 1, wherein the glyconate is selected from the group consisting of ammonium glyconate, lithium glyconate, sodium glyconate, sodium starch glyconate, potassium glyconate, ammonium acid glyconate, sodium acid glyconate, lithium acid glyconate, potassium acid glyconate, ammonium D-glyconate, lithium D-glyconate, sodium D-glyconate, potassium D-glyconate, glyconic acid, glyconic D acid, glyconic L acid, ammonium L-glyconate, lithium L-glyconate, sodium L-glyconate, potassium L-glyconate, magnesium glyconate, magnesium acid glyconate, magnesium D-glyconate, magnesium L-glyconate, calcium glyconate, calcium acid glyconate, calcium D-glyconate, calcium L-glyconate and mixtures thereof.

5. The composition of claim 1, wherein the one or more sulfate is selected from the group consisting of potassium aluminum sulfate, sulfuric acid, sodium sulfate, potassium sulfate, lithium sulfate, ammonium sulfate, magnesium sulfate, strontium sulfate, aluminum sulfate, and mixtures thereof.

6. The composition of claim 1, wherein the composition further comprises (e) one or more salts.

7. The composition of claim 1, wherein the composition further comprises an emulsifying agent, a surfactant, a thickening agent, or a mixture thereof.

8. The composition of claim 1, wherein the composition comprises a) from about 0.11% to about 0.84% of a meta silicate, b) from about 0.08% to about 0.64% of a carbonate, c) from about 0.03% to about 0.26% of a glyconate, and d) from about 0.03% to about 0.26% of a sulfate.

9. The composition of claim 1, wherein the composition comprises a) from about 0.21% to about 0.42% of a meta silicate, b) from about 0.16% to about 0.32% of a carbonate, c) from about 0.06% to about 0.13% of a glyconate, and d) from about 0.06% to about 0.13% of a sulfate.

10. The composition of claim 4, wherein the carbonate is sodium carbonate, wherein the glyconate is sodium glyconate, and wherein the sulfate is potassium aluminum sulfate.

11. The composition of claim 1, wherein the composition further comprises a physiologically-acceptable carrier or diluent.

12. The composition of claim 11, wherein the carrier is selected from the group consisting of liposomes, solutions, creams, emollients, ointments, gels, solid formulations and liquid formulations.

13. The composition of claim 1, wherein the composition is in the form of a liquid, cream, oil, gel, fluid cream, lotion, emulsion or microemulsion.

14. The composition of claim 1, wherein the composition further comprises an active drug substance.

15. The composition of claim 14, wherein the active drug substance is a corticosteroid, metronidazole, sulfacetamide, sulfur, or azelaic acid or a combination thereof.

16. The composition of claim 1, wherein the composition further comprises an active cosmetic selected from the group consisting of desquamatory actives, anti-acne actives, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, skin soothing agents, skin healing agents, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and mixtures thereof.

17. The composition of claim 16, wherein the active cosmetic substance is retinol, a retinol derivative, or a mixture thereof.

18. The composition of claim 16, wherein the active cosmetic substance is allantoin, retinyl propionate, tocopherol, tocopherol derivatives, tocopherol esters, peptides, peptide derivatives, niacinamide, phytosterols, isoflavones, panthenol, panthenol derivatives, salicylic acid bisabolol or farnesol.

19. The composition of claim 13, wherein the composition further comprises a skin lightening agent, a sunscreen agent, a skin conditioning agent, a skin protectant, an emollient, a humectant, or a mixture thereof.

20. The composition of claim 13, further comprising an effective amount of an active agent selected from the group consisting of psoriasis-alleviating agents, anti-microbial agents, anti-inflammatory agents and combinations thereof.

21. The composition of claim 13, further comprises a nutrient selected from the group consisting of vitamins, essential amino acids, essential fatty acids, and cosmetically acceptable salts and esters thereof.

22. The composition of claim 21, wherein the nutrient is selected from the group consisting of vitamin A, vitamin E, essential amino acids, and cosmetically acceptable salts and esters thereof.

23. The composition of claim 13, wherein the composition further comprises colorants, pigments, film-forming agents, thickening agents, shine-control agents, skin conditioning agents, humectants, exfoliants, powders, solidifying agents, spray propellants, fragrances, surfactants, sunscreen, antioxidants, chelators, skin-lightening agents, anti-aging additives, anti-septics, preservatives, anti-microbials, anesthetics, pH-adjusting agents, chaotropic agents, and combinations thereof.

24. The composition of claim 13, wherein the concentration is in an amount effective to treat skin damage.

25. The composition of claim 13, wherein the composition comprises a) from about 0.04% to about 1.6% of a meta silicate, b) from about 0.03% to about 1.2% of a carbonate, c) from about 0.01% to about 0.04% of a glyconate, and d) from about 0.01% to about 0.04% of a sulfate.

26. A method for the treatment of skin damage comprising topically applying to the skin a composition containing an effective amount of the composition of any of claim 1-25.

27. A method according to claim 26 wherein the skin damage is selected from the group consisting of eczema, atopic dermatitis, contact dermatitis, seborrhea, xerosis, rosacea, thermal or radiation burns, wounds, and psoriasis.

28. A method according to claim 26 wherein the skin damage is inflammation or aging.

29. The composition of claim 1, wherein the composition is in the form of a shampoo, lotion or conditioner and comprises an amount effective for treating the hair, skin, or scalp.

31. The composition of claim 29, wherein the composition further comprises a conditioning agent.

32. The composition of claim 31, wherein the conditioning agent is selected from the group consisting of cationic polymers, polyolefins, hydrocarbon oils, silicone gums, silicone oils, and mixtures thereof.

33. The composition of claim 32, wherein the conditioner is present in a proportion of 0.001% to 60% by weight relative to the total weight of the composition.

34. The composition of claim 29, wherein the composition further comprises a detersive surfactant.

35. The composition of claim 34, wherein the surfactant is present in an amount of from about 10 to 90 percent by weight of the composition.

36. The composition of claim 29, wherein the composition further comprises a preservative in an amount from about 0.01 to 6 weight percent of the composition.

37. The composition of claim 29, further comprising a moisturizer.

38. The composition of claim 37, wherein the moisturizer comprises one or more of wheat protein, hair keratin amino acids, sodium peroxylinecarbolic acid, panthenol, tocopherol, or dimethicone.

39. The composition of claim 38, wherein the moisturizer is present in an amount from about 0.01 to 2 weight percent of the composition.

40. A method of treating hair or scalp comprising applying to the hair or scalp at least one composition as defined in any of claim 29-39.

41. The method of claim 40, further comprising the step of rinsing the hair or scalp with water after the applying step.

42. The method of claim 41, further comprising the step of leaving the composition on the hair for a period of time before the rinsing step.

43. The method of claim 41, wherein the composition is an aqueous solution in the form of a mousse, cream, gel, aerosol or non-aerosol spray, or lotion.

44. The composition of claim 1 wherein the (a) one or more metasilicate;

(b) one or more carbonate;

(c) one or more glyconate; and

(d) one or more sulfate are present in a composition for oral care in an amount effective to reduce biofilm concentration in the oral cavity.

45. The composition of claim 44, wherein the one or more metasilicate is an alkali metal silicate selected from the group consisting of sodium or potassium metasilicate, sodium or potassium orthosilicate and mixtures thereof.

46. The composition of claim 44, wherein the one or more carbonate is selected from the group consisting of sodium carbonate, sodium sesquicarbonate, sodium sulfate, sodium bicarbonate and mixtures thereof.

47. The composition of claim 44, wherein the glyconate is selected from the group consisting of ammonium glyconate, lithium glyconate, sodium glyconate, sodium starch glyconate, potassium glyconate, ammonium acid glyconate, sodium acid glyconate, lithium acid glyconate, potassium acid glyconate, ammonium D-glyconate, lithium D-glyconate, sodium D-glyconate, potassium D-glyconate, glyconic acid, glyconic D acid, glyconic L acid, ammonium L-glyconate, lithium L-glyconate, sodium L-glyconate, potassium L-glyconate, magnesium glyconate, magnesium acid glyconate, magnesium D-glyconate, magnesium L-glyconate, calcium glyconate, calcium acid glyconate, calcium D-glyconate, calcium L-glyconate and mixtures thereof.

48. The composition of claim 44, wherein the one or more sulfate is selected from the group consisting of potassium aluminum sulfate, sulfuric acid, sodium sulfate, potassium sulfate, lithium sulfate, ammonium sulfate, magnesium sulfate, strontium sulfate, aluminum sulfate, and mixtures thereof.

49. The composition of claim 44, wherein the composition further comprises (e) one or more salts.

50. The composition of claim 44, wherein the composition is a formulation selected from the group consisting of mouthwash, toothpaste, oral gel, ointment, salve, floss, toothbrush bristle, and dental formulation.

51. The composition of claim 50, wherein the composition comprises a) from about 0.08% to about 3.2% of a meta silicate, b) from about 0.6% to about 2.4% of a carbonate, c) from about 0.02% to about 0.08% of a glyconate, and d) from about 0.02% to about 0.08% of a sulfate.

52. The composition of claim 50, wherein the oral composition further comprises at least one of a binder, an emulsifier, a solvent, a fragrance, a refrigerant, a sweetening agent, a coloring agent, a surface active agent, a lubricant, a thickening agent, a pH regulator, a preservative and a medical component.

53. The composition of claim 52, further comprising an effective amount of an active agent.

54. The composition of claim 53, wherein the active agent is a biologically active agent selected from the group consisting of anti-septic materials, antibacterial materials, anti-inflammatory materials and active ingredients that interdict the attachment, propagation, growth and or colonization of bacteria on teeth.

55. The composition of claim 54, wherein the active agent is an antibacterial agent selected from the group consisting of thimerosal, chloramine, boric acid, phenol, iodoform, chlorhexidine, oral antiseptic, beta-lactam antibiotic, cefoxitin, n-formamidoyl thienamycin, thienamycin derivatives, tetracycline, chloramphenicol, neomycin, gramicidin, kanamycin, amikacin, sismicin and tobramycin.

56. The composition of claim 54, wherein the active agent is a sensory marker selected from the group consisting of a flavor and cooling agent.

57. A method of enhancing dental health by topically administering the formulation of any of claim 50-56.

58. A method of treating or preventing gum diseases and tooth decay by topically administering the formulation of claim 50.

59. A method of promoting the healing of wounds by topically administering the formulation of claim 50.

60. The composition of claim 1 wherein the (a) one or more metasilicate;

(b) one or more carbonate;

(c) one or more glyconate; and

(d) one or more sulfate are present in a sterile aqueous cleaning, disinfecting, storing and wetting solution for contact lenses in an amount effective for removing biofilms from contact lenses.

71. A method according to claim 27, wherein the a wound is the result of a skin break, muscle tear, burn, surgical procedure, infectious disease, or an underlying condition.

61. The composition of claim 61, wherein the composition comprises a) from about 0.08% to about 3.2% of a meta silicate, b) from about 1.2% to about 5.0% of a carbonate, c) from about 0.04% to about 0.16% of a glyconate, and d) from about 0.04% to about 0.16% of a sulfate.

62. The composition of claim 61, wherein the one or more metasilicate is an alkali metal silicate selected from the group consisting of sodium or potassium metasilicate, sodium or potassium orthosilicate and mixtures thereof.

63. The composition of claim 61, wherein the one or more carbonate is selected from the group consisting of sodium carbonate, sodium sesquicarbonate, sodium sulfate, sodium bicarbonate and mixtures thereof.

64. The composition of claim 61, wherein the glyconate is selected from the group consisting of ammonium glyconate, lithium glyconate, sodium glyconate, sodium starch glyconate, potassium glyconate, ammonium acid glyconate, sodium acid glyconate, lithium acid glyconate, potassium acid glyconate, ammonium D-glyconate, lithium D-glyconate, sodium D-glyconate, potassium D-glyconate, glyconic acid, glyconic D acid, glyconic L acid, ammonium L-glyconate, lithium L-glyconate, sodium L-glyconate, potassium L-glyconate, magnesium glyconate, magnesium acid glyconate, magnesium D-glyconate, magnesium L-glyconate, calcium glyconate, calcium acid glyconate, calcium D-glyconate, calcium L-glyconate and mixtures thereof.

65. The composition of claim 61, wherein the one or more sulfate is selected from the group consisting of potassium aluminum sulfate, sulfuric acid, sodium sulfate, potassium sulfate, lithium sulfate, ammonium sulfate, magnesium sulfate, strontium sulfate, aluminum sulfate, and mixtures thereof.

66. The composition of claim 61, wherein the composition further comprises a preservative, a thickener, a buffering agent, a chelating agent, an isotonicity agent or surfactant.

67. The composition of claim 61, wherein the composition further comprises sodium chloride present in a concentration of 0.6-0.9%, at least one microbiological preservative present in concentration of 0.1-0.5% and a chelating agent present in a concentration of 0-0.1%.

68. A method of cleaning a contact lens, which comprises contacting the contact lens with an effective amount of the ophthalmic solution of any of claim 61-68.

69. A method of caring for a contact lens comprising:

(a) manually cleaning the contact lens with an effective amount of the aqueous non-abrasive cleaning solution of claim 61; and

(b) storing the contact lens in the aqueous non-abrasive cleaning solution during a non-wearing period.

70. The method of claim 70 further comprising rinsing the cleaning solution from the contact lens after the non-wearing period and wetting the contact lens with an aqueous wetting solution for the contact lens, the aqueous wetting solution comprising a wetting component suitable for wetting the contact lens.