B7-H1 AND B7-H4 IN CANCER
First Claim
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1. A method of determining the prognosis of a subject with cancer, said method comprising:
- (a) providing a tissue sample from said subject; and
(b) assessing in said tissue sample the presence or absence of expression of B7-H1 and B7-H4, wherein the presence of expression of B7-H1 and B7-H4 in said tissue sample indicates said subject is more likely to die of the cancer than if only B7-H1 or B7-H4 is expressed in said tissue sample.
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Abstract
Methods of determining prognosis of a subject with cancer or determining risk of cancer progression by assessing expression of B7-H4, or B7-H1 and B7-H4 in combination.
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Citations
28 Claims
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1. A method of determining the prognosis of a subject with cancer, said method comprising:
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(a) providing a tissue sample from said subject; and (b) assessing in said tissue sample the presence or absence of expression of B7-H1 and B7-H4, wherein the presence of expression of B7-H1 and B7-H4 in said tissue sample indicates said subject is more likely to die of the cancer than if only B7-H1 or B7-H4 is expressed in said tissue sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of determining risk of cancer progression in a subject with cancer, said method comprising:
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(a) providing a tissue sample from said subject; and (b) assessing in said tissue sample the presence or absence of expression of B7-H1 and B7-H4, wherein the presence of expression of B7-H1 and B7-H4 in said tissue sample indicates said subject is at more risk of cancer progression than if only B7-H1 or B7-H4 is expressed in said tissue sample. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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- 19. An article of manufacture, said article of manufacture comprising a first antibody that binds to a B7-H1 polypeptide and a second antibody that binds to a B7-H4 polypeptide.
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22. A method of determining risk of cancer progression in a subject with cancer, said method comprising:
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(a) providing a tissue sample from said subject; and (b) assessing in said tissue sample the presence or absence of expression of B7-H4, wherein the presence of expression of B7-H4 in said tissue sample indicates said subject is at more risk of cancer progression than if B7-H4 expression is absent in said tissue sample. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification