Nucleic acid isolation methods and materials and devices thereof
First Claim
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1. A method for purifying nucleic acid comprising the step of contacting a sample with a chitosan immobilized to a matrix.
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Abstract
The present invention relates to methods for purifying nucleic acid from a sample using mild conditions that do not affect the chemical integrity of the nucleic acid. The method comprises contacting the sample with an matrix entrapped chitosan solid phase which is able to bind the nucleic acids at a first pH, and then extracting the nucleic acid from the solid phase by using an elution solvent at a second pH.
26 Citations
35 Claims
- 1. A method for purifying nucleic acid comprising the step of contacting a sample with a chitosan immobilized to a matrix.
- 19. An composition for purifying nucleic acid comprising a chitosan copolymer.
- 27. A microfluidic device comprising a microchamber or microchannel having a chitosan immobilized to a matrix therein.
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