Method for Producing Virus-Type Particles Containing an Active Substance
First Claim
1. A method for producing virus-type particles containing an active substance, proteins each having a first amino acid sequence which is derived from a first virus protein and fusion proteins assemble to the virus-type particles, the first amino acid sequence being an amino acid sequence which is adequate for the formation of capsoid-forming capsomers that specifically bind a second virus protein, the fusion proteins having a second amino acid sequence each derived from the second virus protein and specifically binding to one of the capsomers each and a third amino acid sequence which forms the active substance, the proteins and the fusion proteins being co-expressed in yeast cells.
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Abstract
The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed in yeast cells.
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Citations
28 Claims
- 1. A method for producing virus-type particles containing an active substance, proteins each having a first amino acid sequence which is derived from a first virus protein and fusion proteins assemble to the virus-type particles, the first amino acid sequence being an amino acid sequence which is adequate for the formation of capsoid-forming capsomers that specifically bind a second virus protein, the fusion proteins having a second amino acid sequence each derived from the second virus protein and specifically binding to one of the capsomers each and a third amino acid sequence which forms the active substance, the proteins and the fusion proteins being co-expressed in yeast cells.
- 17. Virus-type particles containing proteins each having a first amino acid sequence which is derived from a first virus protein, and fusion proteins, the first amino acid sequence being an amino acid sequence which is adequate for the formation of capsoid-forming capsomers which specifically bind a second virus protein, the fusion proteins having a second amino acid sequence each which is derived from the second virus protein and specifically binds to one of the capsomers each and a predominantly hydrophobic third amino acid sequence which forms an active substance.
Specification