SYSTEM AND METHOD OF ANALYTE DETECTION USING DIFFERENTIAL RECEPTORS
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Abstract
Methods and systems for detecting the presence of analytes are described. A fluid or gas sample containing one or more analytes may pass through a particle-based sensor array. Detection and analysis techniques may be applied to determine the identity and quantity of the analytes.
123 Citations
32 Claims
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1-7. -7. (canceled)
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8. A sensor array comprising:
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one or more particles positioned in one or more cavities, wherein a particle comprises; a polymeric resin bead; and one or more receptors comprising one or more attracting components coupled to the polymeric resin. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A method comprising:
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passing a fluid over one or more particles comprising one or more receptors comprising two or more attracting components coupled to a polymeric resin bead; detecting one or more signals produced by the interaction of one or more analytes in the fluid with one or more of the particles; and assessing the pattern of one or more of the produced signals. - View Dependent Claims (17, 18)
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19. A method comprising:
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passing a fluid comprising one or more analytes over one or more particles in a cavity of a sensor array, wherein a particle comprises one or more receptors comprising two or more attracting components coupled to a polymeric resin, wherein one or more of the analytes associates with two or more of the attracting components; adding one or more visualization agents to the particles, wherein one or more of the visualization agents displace at least one analyte from the particle; and detecting one or more signals produced by the displacement of at least one analyte from the at least one particle. - View Dependent Claims (20, 21)
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22. A method comprising:
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passing one or more visualization agents over one or more particles in one or more cavities in a sensor array, wherein one or more of the particles comprise one or more receptors comprising two or more attracting components coupled to a polymeric resin, and wherein two or more of the attracting components associate with one or more visualization agents; passing a fluid containing at least one analyte over the particles, wherein the particles interact with the analyte, and wherein at least one analyte displaces at least one visualization agent from the particle; and detecting one or more signals produced by the displacement of one or more of the visualization agents from one or more of the particles. - View Dependent Claims (23, 24, 25, 27, 28, 29, 31)
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26. (canceled)
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30. (canceled)
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32. (canceled)
Specification